It is easy to hear in this society the phrase “I am very stressed” because we have more and more demands on us in the workplace or staffand the truth is that it is something that is gradually being used as a “crutch” to associate it with mental fatigue or lack of time. However, the reality is that the great effect that stress has on our body is generating very relevant physical problems that can alter us in the long term.
Its effect. The immune system is a fundamental part of our body that defends us against microorganisms, but also against cells that do not follow a natural division and that, without this control, can continue ahead. generating cancer. That is why taking care of it is fundamentaland constant stress is one of your worst enemies by reducing your ability to act.
There is no need to demonize. To understand the damage, we must first be fair with the stress, since logically there are situations where you have to have stress to be able to stay aliveand without that ‘stress’ our species would literally be extinct a long time ago. And to understand it, if we ‘travel’ thousands of years ago, if a lion chased a human, the body released adrenaline and cortisol, preparing the immune system for possible injuries and enhancing short-term defenses. The problem with modern life is that the “lion” is no longer a specific predator, but the mortgage, work or constant anxiety.
But it is a problem. When stress becomes chronic, it becomes a poison for the body, since, according to different articles, the perpetual state of alert overstimulates the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Here the result is a sustained elevation of cortisol that, paradoxically, ends up causing “glucocorticoid resistance,” which are the molecules that are naturally produced to reduce inflammation.
The body is then flooded with stress hormones, but your cells stop responding properly to them to curb inflammation. And as we have seen on many occasions, long-term inflammation brings more problems than benefits.
The defenses. The immune dysfunction caused by this chronic condition is perfectly documented. An example is in the classic Cohen study which already mapped out the physiological mechanisms that make us more vulnerable to infections, but experimental studies and reviews from 2025 give us an exact cellular x-ray of what we lose.
Among the examples that stand out, we have a drastic reduction of NK cells which are our first line of defense against viruses and tumor cells. Furthermore, both T lymphocytes (which are fundamental cells of the immune system) such as B lymphocytes see their response capacity diminished, making them unable to ‘destroy’ microorganisms that enter our body. But if that were not enough, chronic stress ages the immune system before its time.
In a loop. Perhaps the most fascinating discovery that science points to is the connection between the immune system and mental health through neuroinflammation. Here, chronic stress is literally wearing down the body by continually adapting, causing the immune system to skyrocket. proteins related to inflammation that can travel to the brain and activate microglia, which is the ‘defense’ system of the nervous system.
The result? A neuroinflammatory environment that is directly linked to the development of depression and anxiety disorders. And logically, if we have anxiety, stress will continue to increase, causing more inflammatory proteins to be released that will continue to affect the brain.
It’s not forever. Here science points out that the damage caused by stress is not perpetual, but can be reversed at any time through interventions psychological interventions focused on stress reduction, as well as regular physical exercise. This has shown that chronic inflammation can be reduced and normal immune system cell function restored.
That is why now rest and mental health should not be seen as a luxury, but rather we must begin to see them as an important biological shield that can greatly extend our lives if we manage to keep it under control.
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