The poison of the Cobras is one of the most feared and mortal in the world. AI is very close to neutralizing it forever

After the mosquitoes and the man himself, snakes usually take third place in The list of more deadly animals for the human being. According to estimates of the World Health Organization (WHO), between 81,410 and 137,880 people die every year as a result of the bite of these reptiles. AI can help change this. AI to the rescue. A group of researchers has demonstrated the utility of deep learning tools (Deep Learning) In the design of proteins capable of neutralizing, at least partially, the effect of the venom of some the steps (Elapidae), The snake family that includes the cobras, coral snakes and mambas. Three fingers. The study focuses on the calls “Toxins of the three fingers”(3FTX), called by the form of tridents that have the proteins that make up this family. These compounds are potentially lethal neurotoxins, that is to say they have the ability to attack our nervous tissue and involve a risk to the lives of people who are poisoned. As the team explains, these toxins are responsible for the anti -speakers, the antidotes used to counteract the venom of snakes, are not effective. The reason is that these toxins are capable of “evading” To our immune system, reducing the effectiveness of some treatments. For now, in mice. The team responsible for the development of the new antitoxins put them to the test in mice. The team experienced with different types and doses of poison and different antitoxins, achieving survival rates of between 80% and 100%. The details of the study have been published In an article In the magazine Nature. Lowering costs. The new technique opens a new way to the creation of molecules aimed at counteracting the different toxins that affect people who receive the bite of a poisonous snake, offering new advantages. First, to reduce the time dedicated to the process of searching for new useful compounds in this field. Less time dedicated to research implies a lower cost, but it is not the only factor that would help reduce the “invoice” of antidotes. According to the equipment, the new compounds can be synthesized using microbes, which would avoid traditional production methods. “The antitoxins we have created are easy to discover using only computational methods. They are also cheap to produce and robust in laboratory tests,” stood out in a press release David Baker, study co -author. Better access.Under costs and higher production facilities imply better access to these antidotes, something key if we take into account that it is in developing countries where snake bites more problems cause. “I trust that protein design make treatments against snake bites more accessible to people in developing countries,” Susana Vazquez Torres addswho led the new job. The inheritance of a Nobel. David Baker’s name can be familiar: in 2024 He received the Nobel Prize in Chemistry “For the computational protein design”, a prize he shared with Demis Hassabis and John M. Jumper. Baker’s prize recognized his work in the construction of proteins never observed in nature, all through the combination of amino acid sequences. In Xataka | Some engineers have simulated 500 million years of evolution with an AI. Now we have a fluorescent protein Image | Anil Sharma

Inject your partner poison

Make up is a risk sport. That they tell the male of the religious mantis who has to feel how His head is devoured by the female While his body, automatically, continues to copulate. This practice is less common than what is thought, since it occurs in just a handful of Mantis speciesbut it is not the only stage of the animal kingdom in which The male is killed for the good of the offspring. And there is A hops They have the same customs. Of course, there is an octopus of a concrete species that has a strategy to fertilize the female and survive the process: poison it. Dimorphism. Something important before entering the case of octopus is that there are many animal species with cases of sexual dimorphism extremely accentuated. This implies a difference in size between the sexes, being the case of the mantis one of them. In mammals, males are usually larger than females, since they are the ones that fight for territories and mating, but it occurs backwards in case of raptors, arthropods, amphibians and reptiles. In the octopus, there are extreme cases in which there are females that are up to ten times larger than males. One of those cases is that of the blue line octopus –Hapalochlaena fasciata-. They are small, but tremendously lethal octopus because they are able to inoculate a very powerful neurotoxin that they share males and females. Contrast with its small size: just bigger than a golf ball. Sex and snack. However, the female is twice as large as the male and mating dynamics is not very healthy to say (for the male, of course): due to that imbalance, the female usually ends the life of her sexual partner during the process. However, in a study published in Science Directa group of researchers from the University of Queensland in Australia has discovered that the male has developed a toxic way of surviving mating, literally. Due to that huge difference in size, males cannot develop tactics that they use in other species of octopus, such as a more elongated reproductive arm to inseminate at a safe distance or even arms – character – with the reproductive load that emerges so that the animal can flee. The only thing left to this species is to bite the female to inject neurotoxin, directly. Here we have a complete half -hour sequence: Poison. As we read in Sciencealertresearchers comment that, probably, this evolution has been “an answer both to the need for reproduction and protection”, and what they do is ‘bite’ the female before trying to copulate. They do it near the aorta, injecting the fair amount of tetrodotoxin to paralyze their partner during the process. To check, the researchers placed six couples in different aquariums and observed this practice in all cases. “The females succumb quickly,” they comment, and it is something they observed because they lost reflexes to light stimuli, paid and the pupils contracted due to the loss of nervous system control. Wait, what happened? They also made more precise observations: while the males went from 20 or 25 contractions per minute at rest at 35 or 45 during the intercourse, the females not only suffered an abrupt fall in their heart rate, but stopped breathing completely after about eight minutes of the bite. They point out that none died, so the amount of neurotoxin they inject is very precise or, evolutionarily, the female has developed countermeasures, but the bite on the back of the head was evident. “Once immobilized, males proceed to intercourse and mating ends when the female regains control of her arms and separates the male,” the researchers point out. In this video we can see how the male approaches while the female remains motionless: Sexual Armament Carrera. The researchers comment that they did not directly measure the levels of neurotoxin, but it is a practice that “suggests an evolutionary armament career among the sexes, in which the cannibalism of large females is counteracted by males through the use of venom.” Fruit of this evolution is that the posterior salivary glands of the males, which is where the symbiotic bacteria that produce toxin accumulate, are three times larger than those of the females. They also comment that they are not the only animals that accumulate that toxin in their bodies and that there are fish, mollusks or amphibians that produce it, so they will continue to investigate to identify whether other animals use it in order to reproduce and leave alive from the process. Ah, and something curious of the experiment: in one of the cases, one of the males bit at a point somewhat away from the aorta and the female took less time than the others to wake up: 35 minutes. Speaking, people understand each other, but when hunger enters during intercourse, it is clear that there are species that fail to suppress those cannibal instincts. By the way, Wen-Sung Chung, one of the main researchers, has shared 15 GB of videos of the octopus copulating using these peculiar strategies. Images and videos | Queensland University In Xataka | A whale toured 13,000 km and three oceans to reproduce. It is a record, and also a bad news

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