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We live in a time where people do not stop complement your nutrition with magnesium, collagenvitamins and more. But in recent months you have surely come across the famous ‘peptides’, a compound that has gained quite a bit of momentum in the world of cosmetics under the trend called looksmaxxing and also in bodybuilding. But… Do they have any scientific endorsement? What are peptides? In biological terms, peptides are short chains of amino acids that act as the building blocks of proteins, such as collagen, elastin and keratin. They are naturally in our body from the protein that we administer in our diet, and that the body uses as bricks to build the elements of the skin, muscle, immune system and many more functions. But this is something that has happened from natural biology to the field of cosmetics and nutricosmeticssince it has been seen that when these peptides are applied to the skin, they act as “messengers” that trick the body into believing that it has lost collagen, stimulating its production. In this way an anti-wrinkle effect is promised. What does science say? Unlike many “miracle supplements” that flood the internet, topical and oral peptides do have robust scientific backing, although, as always, keep in mind that you should not expect an amazing miracle when applying them. Among one of the most representative studies we have that of the Spanish Society of Aesthetic Medicine (SEME) which analyzed the effect of biomimetic peptides in patients between 40 and 70 years old. Here it was seen that, after four sessions, the biopsies confirmed real changes in the skin as there was a greater proliferation of collagen and elastin. There is more. Clinical trials with active ingredients such as Matrixyl in 93 people showed also a noticeable reduction in fine lines after 12 weeks of use, and also collagen peptide supplements such as Peptan have been shown in clinical trials to be able to reduce wrinkles around the eyes by 13% and pores by 57%. The dark side. When this becomes an obsession, that is when the problems begin, and again social networks have been a trigger. Here TikTok or Instagram has caused a trend known as looksmaxxing to break out., which in Spanish could be translated as ‘maximize appearance’. And it is nothing more than a subculture, predominant in younger men, who wants to optimize their physical attractiveness to the maximum. While the softmaxxing includes gym routines, haircuts and intense skincare, the most extreme aspect has popularized the use of injectable peptides. Suddenly, it’s not uncommon to see videos of content creators showing off refrigerators full of vials that promise ultra-luminous skin, instant muscle recovery, extreme fat loss, or hyper-defined jawlines. And it is a danger. The big problem with these injectables is that they are often not regulated, and people resort to the Internet to buy them thanks to the legal loopholes created by products under investigation or not suitable for human consumption. Here different organizations have launched alerts warning that using products that have not been authorized by the responsible agencies can cause serious risks such as infections, abscesses or even tissue necrosis. A gym shortcut. Beyond wanting to maximize beauty and reduce the number of wrinkles, in the world of bodybuilding, peptides have burst onto the scene, presenting themselves as a modern alternative to classic steroids. In this way, it is not uncommon to hear about BPC-157, TB-500 or CJC-1295, which are peptides that promise great aesthetic results. His promises. BPC-157 or TB-500 have been dubbed ‘healing peptides’ due to the great fame they have gained by promising regeneration of tendons, ligaments or muscle tears in record time. Another popular group are secretogogues such as CJC-1295 They stimulate the pituitary gland to produce growth hormone ‘naturally’, which enhances muscle growth and fat burning much more quickly than by directly injecting the hormone. Your problems. The problem in the field of bodybuilding is the same as in the aesthetic field, but multiplying the doses. Here science points out that although it is true that the BPC-157 can ‘heal’ tissues, at the moment it has not been approved by the EMA or the FDA for this use because there are a lack of studies to support its safety and the recommended dosage. Furthermore, playing with hormonal levels does not come for free, and without going any further, enhancing the release of growth hormone to have more muscle increases IGF-1 levels. And this in the long term can cause insulin resistance and, therefore, open the door to type 2 diabetes in several years. That is why the recommendation is always to avoid their consumption without medical supervision and logically if they have not been approved by the agencies responsible for drug control. Images | Norbert Buduczki In Xataka | Magnesium, creatine, collagen: we are taking supplements above what science believes is useful