Reaching 100 years old is a statistical feat, but do it while avoiding diseases as serious as cancer or surviving a serious infection is almost a superpower. For decades, science has been asked what makes centenarians biologically special to reach where few reach, and the clearest answer we have right now is that your immune system ages at a completely different rate than the rest of us mortals.
The passage of time. As we age, our body deteriorates at a more or less rate depending on how much we have taken care of it with the lifestyle we have wanted to follow. But something that cannot be skipped is the generation of a low-grade chronic inflammation called ‘inflammation‘ which is the perfect breeding ground for cells to deteriorate, cardiovascular problems and tumors to appear.
An exception. But as a recent review points out published in Nature With Spanish participation, it has been seen that centenarians have an extremely efficient system for “cleaning” damaged or senescent cells before they cause problems, something that is very efficient in young people, but becomes less so with the passage of time.
But in addition, compared to the impoverishment of the intestinal flora common in old age, centenarians preserve a spectacular microbial diversity, also lacking the pro-inflammatory obesity that affects a large part of the population. But not everything is natural genetics, since the habits one follows and the environment in which one has lived shape part of the genetics by activating or deactivating genes, protecting them from accumulated damage.
The paradox of cancer. One of the most fascinating data that medical research reveals is the relationship between centenarians and cancer. Although the risk of suffering from tumors increases with age as more genetic errors accumulate, when the 100-year barrier is exceeded, the curve falls sharply. This means that the incidence of cancer in people over the age of one century is less than 4%. And again the question is: why?
Here, science suggests that centenarians have very high selective cytotoxicity, that is, cells with problems inside are destroyed before they get worse. Here the protagonists are the immune cells that maintain relentless anti-tumor surveillance, eliminating malignant cells with the efficiency of a young adult, but maintaining a high tolerance towards their own healthy tissues to avoid autoimmune diseases such as the famous rheumatoid arthritis that is quite common in older people.
We are moving forward. The study does not remain only in the laboratory, but compiles evidence about the “real world” such as the famous ‘Blue Zones’ of Okinawa (Japan) where great longevity among its inhabitants stands out. Here the autopsies on the corpses indicated that their coronary arteries were obstructed by age but that they had only suffered massive fatal heart attacks. Here the body had found ways to adapt and survive.
During the worst waves of COVID, there have also been cases of centenarians in residences who managed to survive the virus even without being vaccinated. This fits with the published data in 2023 by Nature Aging on supercentenarians in Boston, who revealed an “elite” immune system, trained by a lifetime of environmental exposures that formed a profile highly resilient to infections.
For the future. Although genetics are important, what we can control much better are lifestyle habits and their effect on how certain genes are expressed. In this way, it is about investigating the people who survive the longest with the aim of ‘copying’ what they do to find the Holy Grail of longevity.
Images | freepik
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