A macro study warns that well-being plummets if you have not had a partner at 25

There was a time when being single at 20 was something seen as a style of independence and self-discovery. However, science has put a figure on a table that changes this concept that we could have in our minds: from the age of 25, the emotional well-being of those who have never had a relationship begins to suffer. A change of vision. It was the University of Zurich which has decided to take the step of investigating the “social clock” of the youngest in society, which has given an article published in the Journal of Personality and Social Psychology. Right now, many studies were focused on the impact of dating apps and how the flirting paradigm has changed today. But they have taken a turn to investigate 17,390 young people from Germany and the United Kingdom, tracking their lives from ages 16 to 29 with the aim of correlating their emotional life with their romantic situation. A “single” profile. One of the conclusions most striking of the research of Michael Kremer and his team are the ones who stay single the longest. Against the stereotype that being single is a purely bohemian choice, data shows clear patterns. First of all, men are more likely to remain single for a long timeThat is, they have never had a romantic relationship. But in addition, there is a direct correlation with a high academic training, since young people with higher educational levels They tend to delay their first relationship. The environment. But a great paradigm shift in recent years is undoubtedly in poor access to housing. The fact that many young people continue to live with their parents is undoubtedly a great determining factor in this love trajectory for young people. The turning point. Until age 23 or 24, there are no critical differences in life satisfaction between those who have had a partner and those who have not. However, upon crossing the 25-year threshold, the gap widens. In this case, the researchers detected that young people who have never been in a relationship show significantly higher levels of loneliness and depressive symptoms as they approach 30. According to the authors, this is because the social environment begins to put pressure implicitly, and the comparison with peers (who already establish long-term commitments) generates a feeling of exclusion. The healing power. But beyond the negative part for all those who have spent 25 years without a partner, the reality is that they have also seen that the first relationship It has incredible healing power. Especially when we talk about these long-term singles who find a partner. The transition to the first relationship brings an immediate increase in life satisfaction and a drastic drop in feelings of loneliness. Interestingly, although loneliness decreases, depressive symptoms take longer to stabilize, suggesting that the lack of previous experience leaves an emotional imprint that is not instantly erased with the first “I love you.” Social pressure. This work opens an interesting debate about mental health in the era of dating apps and job insecurity. Although society increasingly values ​​autonomy, the human brain appears to still respond to traditional social milestones. For Michael Krämer and his team, the problem is not singleness itself, but the mismatch between the desire for connection and the reality of a solitary life that extends beyond what the individual, or his or her environment, considers “normal.” And today there is above all pressure from the family that does not stop asking classic questions about when someone is going to have a partner to take them to family events. This is nothing more than a big problem for young people who see how they are arriving late to something that for many people is normal, especially if we look at the past where relationships and marriages increasingly emerged much earlier. Images | Vitaly Gariev In Xataka | Traditional couples have always aspired to live under the same roof. The LAT believes it is a huge mistake

The atlas of side effects (positive and negative) of Ozempic discovered | Health and well-being

All medications have side effects, just take a look at any leaflet to see this. But there are not many cases in which these amount to the main effect. This is what happened a few years ago with GLP-1 agonists, medications used for decades to treat type 2 diabetes that began to demonstrate weight-loss effects. After several reformulations, new commercial brands, such as Ozempic and Wegovy, became an effective way to end obesity. But science is proving that there are many other side effects that could become major ones. GLP-1 is a molecular Swiss army knife, a kind of all-purpose drug. They affect our bodies in ways we still don’t fully understand. But today we are closer to listing. A team of scientists from the University of Washington School of Medicine has published the first detailed atlas of the side effects of these drugs. They have found benefits for cognitive and behavioral health, while revealing an increased risk of developing pancreatitis and kidney conditions. “Until now we had seen anecdotes and reports here and there. “Some people saying that it can affect this or that,” explained its main author, the clinical epidemiologist, in the presentation of the study. Ziyad Al-Aly, from the John J. Cochran Veterans Hospital. “But no one, no one had thoroughly investigated the effectiveness and risks of GLP-1 and all the ways it can affect health.” The study was published this Monday in the journal Nature Medicineshowcase of the best world science. More information “We did an analysis that comprehensively mapped the associations between GLP-1 and 175 potential health effects,” Al-Aly notes. The benefits, beyond weight loss, included a lower risk of substance use disorders and a reduction in suicidal ideation, schizophrenia, and other psychotic disorders. They also observed a reduction in cognitive disorders, such as Alzheimer’s and dementia. And finally, a reduction in the risk of clotting disorders, including stroke. “We found that these drugs have a wide range of beneficial effects, but all this does not come without risks,” warns the expert. The study confirms that, in some cases, they can cause gastrointestinal problems, such as nausea and vomiting. This is quite common and has already been documented in some patients. An increased risk of gastroparesis or stomach paralysis in rare cases and an increased risk of low blood pressure have also been seen. The analysis also notes that the drug may increase the risk of sleep problems and headaches, kidney stones, and drug-induced kidney inflammation. For these reasons, the authors recommend that, when evaluating this treatment, it should always be done under medical supervision and after an individualized analysis. “It is an observational study, although it has a large database and has been carried out for a long time,” he explains. Christopher Moralesan endocrinologist at the Virgen Macarena University Hospital in Seville, who was not involved in the study. The study does not demonstrate, therefore, that the medication is the cause of the listed effects. But these are consistent enough (risk reduction between 10 and 20%) and the database large enough (almost two million patients over three years) to think there is a direct relationship. “With Big Data you can scrape these results in very large databases and this is positive. But we must remember that here we can only verify association, not causality.” The objective of this research, in the words of its own authors, was not to analyze a specific effect and demonstrate causality, but to build an atlas of the association of risks and benefits of this relatively new medicine. “It’s like when Christopher Columbus arrived in America, and he thought about mapping it to get his bearings,” explains Al-Aly. “This is what we are doing, drawing a landscape of benefits and risks.” This opens the door to the possibility that in the future, after many reformulations and research, we can talk about an Ozempic for dementia, alcoholism or Alzheimer’s. There is still a long way to go, but this study has drawn a first map to locate the path. And there are many companies willing to embark on this adventure. There is currently a scientific and commercial race to find the next revolutionary use of GLP-1 agonists. Everyone has in mind the case of Novo Nordisk, the Danish laboratory that presented Ozempic in 2018, and which today has a stock market capitalization of 382,000 million dollars, which makes it the largest company in Europe. This has enormous business and economic implications, but from the scientific world, the question is different. How does an anti-diabetes drug have so many and varied effects? “Medicines don’t work surgically. They are designed to do one thing, but the reality is that this is almost never the case,” reflects Al-Aly. “Biology is complex and multiple, and if you touch one thing you will create a network of various effects.” GLP-1 acts on the intestine, but also on the brain, affecting areas that are involved in impulse control and reward signaling. This would explain why they help mitigate addiction problems. These medications would also affect the blood vessels, and in doing so have a potential effect on the heart. There is research that suggests that they also reduce inflammation, including that of the brain, which could explain their protective effect against neurodegenerative diseases. “But there is also another simpler theory that can explain all these positive health effects,” explains Al-Aly. Obesity is considered a disease in itself, but also the gateway to many others. It is the fifth risk factor for death in the world and every year 2.8 million adults die as a result of this condition. “When we treat obesity, it is normal that this affects other diseases, since it is the mother of them all,” summarizes Al-Aly. The expert has not yet decided, with the available scientific evidence, on which of these two theories has more force. The first would mean that we are talking about a miracle drug with multiple uses. The second would be less profitable for companies, would fill … Read more

Tell me what bacteria live in your intestine and I will tell you who your friends are | Health and well-being

Mencius, a Chinese philosopher, wrote a handful of centuries ago that “friendship is one mind in two bodies.” Modern science could add another element: friendship is also a microbiota in two bodies. A study has found that the more people interact, the more similar the composition of the microorganisms living in their intestines becomes, even if they do not live in the same household. The investigation, recently published in the magazine Naturealso ensures that an individual’s microbiome is determined not only by their closest social contacts, but also by the connections of these contacts. That is, the friends of your friends. To know the details of this investigation you have to take a trip to the western heart of the Honduran jungle. It was in this Caribbean country where scientists from Yale University worked for ten years until they recruited a group of 1,787 adults, spread across 18 isolated villages, to donate a sample of their feces. All participants had a traditional diet and practically did not consume antibiotics or other medications. Nicholas Christakis, lead author of the study, explains that they were “very lucky that the participants were helpful and engaged.” The scientists needed to be able to trace each of the volunteers’ contacts with certainty, something that would have been much more complicated to do in cities like Madrid or Barcelona. The towns of Honduras, in this case, were perfect. More information Before continuing to advance with the results of this research, it is worth explaining what the microbiota is and why it is important. Francisco Guarner, director of the Digestive System Research Unit at the Vall d’Hebron General Hospital in Barcelona, ​​has a definition: “It is the bacteria communityviruses and fungi that colonize the digestive tract. We could think of it as another organ of the human body, a set of biological capacities that help the survival of an individual.” Although this organ It lives within us, it functions under its own rules and hierarchies. It is organized in its own way and it is not easy to manipulate it. “It is essential for the digestion of food. It provides us with many enzymes and metabolic pathways that humans do not have,” adds the expert. Thanks to the microbiota we can, for example, digest fiber. They are also essential for the development of a balanced immune system. For decades, science has explored the composition of the microbiota to understand how it is generated in each person. Mireia Vallés Colomer, director of the Microbiome Research Group at Pompeu Fabra University, details that vertical transmission had been, until now, the most likely explanation. “We receive these microorganisms, in large part, from our mothers, through childbirth and breastfeeding. We also share bacteria that our grandmother passed to our mother,” he details. However, the new study ventures that the microbiota changes throughout life, and that those largely responsible for these changes are our social contacts. A horizontal transmission. “We were very surprised by the reach of microbes that networks of people share. In fact, we can predict who your friends are based on how similar the microbes in your stool are to theirs,” says Christakis. Data suggests that people living in the same house share up to 14% of the microbial strains in their intestines. While those who do not live together, but usually spend time together, share 10%. The research has also been able to determine that individuals who live in the same town, but who do not usually interact too frequently, share only 4%. There is, the authors say, a chain of transmission because friends of friends share more strains than would be expected by mere chance. The transmission method There is a question that continues to swirl around this research and that is to understand how strains are transmitted bacteria from one microbiota to the other. “We do not have a conclusive answer about how this transmission occurs,” says Vallés. And he adds: “What is hypothesized is that what reaches the intestine has to pass through the mouth. “Many bacteria in the microbiome don’t tolerate direct contact with oxygen for very long, so close contact is needed, but we don’t know exactly what that looks like.” Guarner, however, details that “the fecal-oral route “It seems to be the most important transmission vector.” That is to say, although we clean ourselves and more or less control our hygiene, in some previous studies it has been detected that the bacteria that are typically found in the intestine also appear on the hands. This is how they then reach the mouth. Some of the bacteria manage to survive this journey from the intestine because they travel in the form of spores, similar to those of fungi. “With this transmission mechanism it does not have to be extremely direct contact, it can be through a towel or clothing,” details Guarner. There is no need to be alarmed. This transfer of microorganisms It is what, in some way, keeps us alive. So much so, that new lines of research on the relationship between microbiota and health suggest that a healthy and fit community of microorganisms has an impact on several aspects of our well-being. Some researchers are trying to establish a direct relationship between the microbiota and non-communicable diseasessuch as cardiovascular diseases, diabetes and even depression. Guarner explains: “This is still a bit speculative, but normally what happens is that these types of diseases are associated with a poor microbiome.” Vallés contributes that “it has been observed that people with the so-called ‘modern diseases’ suffer an alteration in the composition of their microbiome.” But it is not that there is a particular bacteria responsible for these diseases, but rather it is the loss of diversity in general that worsens the state of health. In this case, the research opens the door to continue analyzing whether these non-communicable diseases, in fact, do have a transmissibility factor. And if an entire community of people has a weakened microbiota, these diseases could proliferate more easily … Read more

Johann Hari, journalist: “The idea that obesity is a sin is deeply rooted in our culture” | Health and well-being

A couple of days after starting to take Ozempicsays the journalist and writer Johann Hari (Glasgow, 46 years old), he woke up with a strange sensation, unknown to him: he was not hungry. He got out of bed and went out to have breakfast at the bar, the usual breakfast, a chicken sandwich with mayonnaise. He took a couple of bites and couldn’t finish it. It was full. The medicine, belonging to that generation of drugs that have revolutionized The fight against obesity by imitating the effect of a hormone (GLP-1) that tells us when we are full, was restoring a lost perception: that of satiety. Hari tells this and other anecdotes about his experience with these medications in his new book Lose weight at any price. How Ozempic and other drugs are going to revolutionize our diet and our physical and mental health (Península), which reaches bookstores today. In these pages, the journalist, who has been overweight since he was young, embarks on a journey, accompanied by obesity experts and scientists who have participated in the development of the new drugs, for the benefits and risks of these treatments, the uncertainties that surround them and the uncertain scenarios that open in the field of health and beyond it. The journalist attends EL PAÍS by videoconference from London. More information Ask. He has spoken to many scientists. What has impressed you the most about what they have told you? Answer. Which obesity it really does you. Since I was seven years old I knew that being overweight is not good for your health, but I was surprised by the evidence of how serious it is. If you are obese, you are much more likely to suffer a heart attack, stroke, dementia and cancer. If you are obese by the time you are 18, you are 70% more likely to develop type 2 diabetes. And diabetes is the leading preventable cause of blindness in the UK and limb amputation in the US. Q. He assures that these anti-obesity drugs are destined to be the defining medicine of our time, like birth control pills or Prozac at other times in the last century, for example. Why do you say it? R. Because obesity is the biggest cause of death in the Western world. And now we have a medicine that, if you take it, reverses it and puts an end to it. It’s amazing. So all of us who are overweight or obese have a choice, but we have to compare the risks of remaining obese with the risks of these medications and think about it a lot. (These drugs) They are going to have enormous effects. Q. How can they change our lives and our culture? R. The change is enormous. Jefferies Financial, which is a financial consulting firm, made a report for American airlines saying that they may have to spend much less money on jet fuel, because it costs more money to fly with heavier people and that is going to be a much smaller population. Also in Los Angeles there has been an increase in demand for jewelers to change and adjust wedding rings because people have lost so much weight that the rings no longer fit on their fingers. Approximately 20% of Americans have already tried these medications. This is huge. This is an astonishing scientific advance that will profoundly change society for better and worse. “The foods we eat are undermining our ability to feel full” Q. Regarding this negative part, he exposes some issues that the consumption of these medications entails, such as the risk of losing the culture of body positive or what would happen if people with eating disorders access these drugs that help them lose weight. Have you found answers to these questions? R. The invention of these drugs is like the discovery of fire. Fire is a great tool if I use it to heat my house, but it is terrible if I use it to burn my house down. And in the same way, when something as powerful as this is discovered, it will have great positive effects and great negative effects. If you are overweight or obese and start taking these medications, for example, you are 20% less likely to have a heart attack or stroke in the next 18 months. But you also mentioned something that worries me a lot: when you take these medications, you eat much less; and that’s good if you’re obese like me, but people with an eating disorderanorexia for example, if you are thin and start taking these medications, you can kill yourself with them. Therefore, one of the things we must do is regulate these medications very strictly. Q. The book also delves into what makes ultra-processed foods so addictive. Do they cause a kind of short circuit in our brain systems? R. If you look at a photograph of a beach in Spain in 1979, the year I was born, everyone is very thin and you wonder: where are the obese people? So, obesity was very low. Modern humans have been around for 300,000 years, but obesity was extremely rare. And basically, during my lifetime, it exploded. What happened? We know the answer: Obesity skyrockets everywhere people make a change, when they go from eating mostly fresh foods they prepared that day to eating primarily processed and ultra-processed foodsThat is, food is made up of chemicals in factories in a process that is not even called cooking, it is called making food. This new type of food affects us in very different ways. The foods we eat are undermining our ability to feel full and what these new medications do is restore the feeling of satiety. Q. And what about the industry’s responsibility in this context? R. Need regulate the food industry to prevent children from being exposed to these foods that make them sick and undermine their ability to feel full. I’m talking about a long-term solution and we … Read more

Patric Gagne, psychologist: “The antisocial traits of politicians are confused with strength and people are attracted to it” | Health and well-being

“I’m not bad, it’s just that they have drawn me like that.” The ex-therapist Patrick Gagne (Los Angeles, USA, 49 years old) paraphrases Jessica Rabbit—a cartoon character from Who Framed Roger Rabbit? (Robert Zemeckis, 1988)—when recounting his criminal activities, such as stealing Ringo Starr’s glasses, breaking into homes or taking other people’s cars for night getaways. This UCLA student and doctor in clinical psychology recognizes that she does not feel like others, it is difficult for her to empathize and she must make an effort to tell the truth. If feelings were colors, Gagne would only have the basic ones, such as sadness or joy, but not the complex ones, such as regret, guilt, jealousy, nor love in its conventional form, although she is married to the love of her life and has two children. With his memories, Sociopath (Planet)seeks to promote empathy towards those who suffer from psychopathic and antisocial disorders, although it warns that the term that gives it its title is outdated and is confused with antisocial personality disorder. In the US, it is associated with serial killers, while in Spain “psychopath” is more used. According to the writer and journalist Álex Grijelmo, “sociopath” carries in English the idea of ​​“misfit”, a nuance that does not exist in Spanish. But as some psychologists understand, labels only indicate one direction and the essential thing is to understand the person as a whole. The interview takes place by videoconference on January 20, just after the return to the Oval Office of a president with characteristics similar to those described in the book. Ask. How do you define sociopath? Answer. Sociopathy, psychopathy, and antisocial personality disorder (ASD) are related, but different. The term sociopath, which is no longer used clinically, is now included within psychopathy, which is divided into primary (biologically determined, lacking social emotions such as guilt and empathy) and secondary (caused by the environment, capable of learning social emotions). Sociopathy is associated with secondary psychopathy. APD is a broader diagnosis that can encompass both sociopathy and psychopathy, although not all people with APD are sociopaths or psychopaths. Q. It is so complex that diagnoses can vary depending on the therapist. R. The challenge lies in the etiquette. Words like “psychopath” and “sociopath” are highly stigmatized. I heard one therapist suggest reclassifying sociopathy as “low affect disorder” to reduce stigma and better address the behaviors. A common misunderstanding is that sociopaths and psychopaths cannot feel, but we experience basic emotions, such as happiness and fear. The challenge lies in social emotions, such as love, empathy and compassion, which are learned, not intrinsic. Q. What did your doctoral studies teach you about the connection between sociopathy and anxiety? R. Primary psychopaths cannot experience social emotions or anxiety, while secondary psychopaths or sociopaths do feel anxiety. Treating anxiety can help sociopaths learn social emotions. In my case, the anxiety came from fear of rejection due to my lack of emotion. As a child, I hid my true self to fit in, but once I accepted that I didn’t need to be like everyone else, the anxiety disappeared. Although I still feel apathy, I no longer force emotions, and it is important to be surrounded by empathetic people. As a therapist, I learned that understanding others, even just intellectually, is key. Humanity is diverse, and mutual understanding benefits everyone, regardless of emotional capacity. Q. As if having full access to emotions could magically solve everything… R. Look, from my perspective it doesn’t sound that great (laughs). Q. So does treating anxiety to address sociopathy offer hope? R. Absolutely, I wrote my book to show that there is light at the end of the tunnel. Sociopathy exists on a spectrum, with most cases being mild to moderate. Focusing only on the extremes ignores these milder forms, which could escalate to more severe cases. It’s like only recognizing stage 4 cancer, ignoring stages 1, 2 and 3; Something similar happens with psychopathy. In our society emotions are often heightened; I encourage more acceptance and less anger.” Q. His difficulties in feeling emotions have not implied lacking a moral code, like when he chose “not to hurt anyone.” R. Correct. I am often asked what stops me from murdering someone if I feel no guilt or remorse, and my answer is: I hurt people all I want, but that amount is zero. It seems crazy to me that people believe that guilt and shame are necessary to prevent harm or crime, implying that human beings would always want to harm without these emotions. It is a self-destructive argument. Q. Is there hypocrisy in a society where people without diagnoses of mental disorders do not have to justify their bad actions? R. People with psychopathic and antisocial disorders are criticized for lacking empathy, but most neurotypical people deny it to them. Empathy is often learned through parenting, and a child who struggles in this regard usually doesn’t get much of it either. It is hypocritical to expect psychopaths to show empathy when it is not extended to them. Q. He says feeling accepted is liberating, but accepting those who don’t follow social norms is rare. R. Historically, those who are different are not easily accepted. My emotional difficulties don’t mean my feelings don’t matter. Psychopathy, sociopathy, and APD are often labeled as aggressive disorders, but we should focus on behavior, not emotions. I challenge the idea that children who lack social emotions like guilt are “bad.” They should learn to experience these emotions in a way that works for them, which could prevent destructive coping mechanisms. “Antisocial or narcissistic personalities thrive in professions where emotion can be an obstacle, such as politics.” Q. Unwanted loneliness has been his greatest suffering, but despite the difficulty in making friends, he managed to do so. How did he get it? R. When I accepted my differences and acted authentically, I found people who accepted me for who I am. This is true for anyone: self-acceptance leads to finding … Read more

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