We thought that quenching hunger with Ozempic was the definitive remedy against obesity. Until we look at the muscle
The revolution of drugs as they are OzempicWegovy or Mounjaro have undoubtedly marked a before and after in the approach to obesity, which previously went under the knife when measures focused on lifestyle changes failed. A priori, we are sold the idea of having a very pronounced weight loss, but the reality is that many patients are falling into protein malnutrition and losing a large amount of muscle mass. We are getting more data. We do not know the drugs completely when they begin to be marketed, but as patients use them, they emerge. new side effects or situations that pharmaceutical companies had not initially imagined. Here a revealing new studywhich will be presented at the European Obesity Congress, has put figures on these effects of malnutrition that accompany successful treatments. And all this indicates that the strategy followed with Ozempic must be changed so that doctors can give precise indications of the nutritional strategy that must be followed during the treatment period to avoid serious health problems. Not having an appetite is bad. A priori, those who take Ozempic want to have less desire to eat, and for it to practically be a task that becomes an obligation in order to survive. But the problem is that people end up having too little hunger, as a new scientific study has shown. analyzed over 5,700 days of nutritional data of 332 overweight adults between July 2025 and 2026. What was seen. Of all of these, the 116 users who were taking drugs like Ozempic consumed drastically fewer calories than the control group, something that was quite expected, but the most important thing was the protein intake that plummeted when the drugs were taken. Specifically, medicated patients consumed an average of 53.8 grams of protein per day, and adjusted to their body weight, this amounts to just 0.6 g/kg/day. To put it in perspective, 88% of these patients fell well below the official recommendation of consuming 0.8 g/kg/day of protein, and far from optimal levels for preserving muscle during weight loss. The reason. Lack of hunger literally makes people skip meals, basically because they do not have that physiological need to put anything in their mouth. Here the study could see that patients taking Ozempic or similar skipped 40.4% of dinners, 31.3% of breakfasts and 30.5% of lunches. In this way, by reducing eating to a few moments of the day, it is almost impossible to achieve the around 25 grams of protein per meal that the body needs to synthesize new muscle and maintain the structure it has. It has consequences. In medicine, the fact of losing muscle mass is what is called sarcopenia and until now it was mainly associated with people who were not physically active, such as the elderly or those who were bedridden. Here scientific reviews suggest that between 25% and 40% of all the weight lost by users taking Ozempic is muscle. And in a very important proportion with respect to fat loss, making it so that almost for every two kilos of fat lost, one is muscle. In older adults or patients with type 2 diabetes, the situation is even more serious, since high doses of semaglutide accelerate sarcopenia, reducing vital metrics for longevity and quality of life, such as grip strength or walking speed. In addition, severe calorie restriction brings with it deficiencies of micronutrients such as vitamin D, vitamin B12 or iron. How to avoid it. Here, medical guidelines increasingly point to a personalized approach in which a highly nutritious diet is established to prevent the patient from having a macronutrient deficiency while losing weight. This is why it is already being recommended that during weight loss it is recommended to increase protein consumption from 1 to 1.6 grams of protein per kg of weight, prioritizing a minimum of 20-30 grams at each meal. In addition, a ban should be established on skipping meals, with eating times having to be very measured, even a little, but at different times throughout the day to avoid prolonged fasting. Maintain muscle. This should be the primary objective and that is why, along with a diet rich in protein, strength exercise with weights, bands or even calisthenics should be encouraged. In this way, the body has the signal to maintain the amount of muscle despite the fact that there is a loss of fat due to the medication. And here the objective is to lose weight, but without having to remove the bricks that are literally building our body, since if we manage to lose weight, but are left without muscle mass, the quality of life is not going to be the best. Images | Haberdoedas Anastase Maragos In Xataka | Ozempic’s “great rebound”, in figures: science reveals that the weight returns four times faster than with a diet