30% of depressions do not respond to pills or psychotherapy. A psychiatrist’s idea: treat them with ultrasounds

Depression is a truly complex disorder, which in 30% of cases do not respond to treatment conventional. Neither pharmacotherapy nor psychotherapynor the transcranial magnetic stimulation (used to treat OCD) appear to offer lasting relief to those who become trapped in the more resistant states of the disease. And although at first they can be ‘given up as lost’, the Argentine psychiatrist Salvador Guinjoan He is already working on another avenue of treatment. The idea. The psychiatrist, researcher Laureate Institute for Brain Research from Oklahoma, is working on an alternative that uses more physics than psychiatry for these patients who a priori had no other type of solution. This is based on the low intensity focused ultrasound, what is known as LIFU (Low-Intensity Focused Ultrasound). During the recent Conference on Updates on Neuromodulation held in Seville by the Spanish Society of Clinical Psychiatry, Guinjoan explained that the objective is quite ambitious: to modify the electrical activity of the brain circuits involved in psychiatric symptoms without the need to open the skull or implant an electrode as he explained. in an interview to El País. What is LIFU. This technology uses mechanical energy instead of electrical or chemical energy. Its transducer generates ultrasonic waves that are capable of passing through the skull and concentrating the energy at a very specific point in the brain, subtly modulating the mechanosensitive ion channels of the neurons. In practice, this alters neural communication in regions that are involved in emotion, motivation, or decision-making. But the important thing in this case is that unlike traditional deep stimulation (DBS), which requires surgery and permanent implants, LIFU allows completely reversible interventions with high anatomical precision. According to Guinjoan, the method opens the possibility of observing, for the first time, causal relationships between a specific brain circuit and a clinical symptom: “If modifying a circuit changes the symptom, we can begin to understand the cause,” he points out. The bibliography supports it in these cases, since previous research, such as those carried out in the Massachusetts General Hospital and published in Nature Neuroscience (2024), had already shown how LIFU can influence deep regions such as the amygdala or thalamus without visible tissue damage. Now, the challenge is to transfer that precision to the psychiatric field. Key points. Guinjoan and his team focus their trials on two key markers of resistant depression: anhedonia (inability to experience pleasure) and the persistence of negative thoughts. Both phenomena seem to be related to connection circuits between the prefrontal cortex and the basal ganglia. And it is precisely in this circuit where the psychiatrist wants to intervene with LIFU. The researcher suggests that modulating the subcircuits that connect the prefrontal cortex and the basal ganglia with ultrasound can alleviate these characteristic symptoms without resorting to surgical interventions and perhaps without more medication in the future. And although at the moment there is still a long way to go, pilot studies in the United States point to sustained symptomatic improvements after several sessions, with mild side effects such as temporary headaches. The ethics. The ability to literally reprogram the brain without invading it opens up questions that go beyond medicine. Guinjoan agrees with neuroscientist Rafael Yuste, promoter of the neurorightsin which it is urgent to regulate the non-therapeutic use of these technologies. Although the border between treating a disease and enhancing mental performance is increasingly blurred. Unlike other home neuromodulation tools, such as transcranial electrical stimulation (tDCS) devices that They are already sold for personal useLIFU requires high-precision neuronavigators and a specialized clinical environment. Guinjoan does not believe that it will become a domestic technology, but he does imagine a future where each patient receives a personalized neuromodulation treatment, adjusted to their specific neural map. The future. If ongoing trials confirm efficacy, focused ultrasound could be incorporated in the next decade into the arsenal we have in the treatment of resistant depression, anxiety or even schizophrenia. All this without having to enter an operating room. Something that could also represent a new leap in psychiatry as we know it and a paradigm shift in the therapeutic approach to this type of pathology. Images | Fernando @cferdophotography Robina Weermeijer In Xataka | There are people eating carrots like rabbits because they think it will make them tan. There’s just one little problem

50 years of research on depression psychotherapy leave a surprising fact: we have not improved anything

Since the 70s, hundreds of studies have examined the effects of psychotherapies against the depression. They have done it with many different experimental approaches and designs. They have done it insistently and, as if that were not enough, in an increasing number. That has allowed us to know two things: the first is that psychotherapies They are effective. The second is that this effectiveness has not moved an apex in 50 years. How can we know? To begin with, thanks to Pim Cuijpers, Professor Emeritus of Clinical Psychology at Amsterdam University. He and a team of researchers They gathered 562 randomized controlled trials that had been published in the last 50 years. These essays are the highest methodological quality that are currently (although, as the authors point out, average Caldiad is not as high as it should). In total, the researchers gathered information of 66,361 patients. Most American adults, but with a significant number of people from other countries. From there, they only had to weigh the interventions, the results and see what happened. What did they find? To begin with, they found that psychotherapies work. In fact, his conclusions were that, as the years go by (and studies), the “evidence that psychotherapies are effective is solid and grows over the years.” The surprise was not that, of course. The surprise was that, for many studies that have been added over the years, “they found no sign that the effects of therapies (psychological against depression) have improved.” None. The effectiveness of these treatments has remained surprisingly stable throughout all these years. And how does all this leave psychotherapy? In a strange situation. In a context in which the consumption of benzodiazepines does not stop growing (and, remember, Spain is World Ansiolithic Consumption Leader With more than 91 daily doses per 1,000 inhabitants), psychotherapies appear as an effective solution; But we are not improving. That is, we have a tool, but we cannot climb it. If the problem continues to grow (and is doing it), we will need more and more resources. Resources that, from the financial crisis and despite the concern of recent years, do not seem to be arriving. The question is no longer “What are we failing“,” Why we can’t improve more “,” where is what limits us to go further “, which also: the question is how we do it better. And it is urgent to find an answer. Image | Cuijpers et Atls | Nik Shuliahin In Xataka | Work stress as germ of depression: work pressure enhances mental disorders

Patric Gagne, psychologist: “The antisocial traits of politicians are confused with strength and people are attracted to it” | Health and well-being

“I’m not bad, it’s just that they have drawn me like that.” The ex-therapist Patrick Gagne (Los Angeles, USA, 49 years old) paraphrases Jessica Rabbit—a cartoon character from Who Framed Roger Rabbit? (Robert Zemeckis, 1988)—when recounting his criminal activities, such as stealing Ringo Starr’s glasses, breaking into homes or taking other people’s cars for night getaways. This UCLA student and doctor in clinical psychology recognizes that she does not feel like others, it is difficult for her to empathize and she must make an effort to tell the truth. If feelings were colors, Gagne would only have the basic ones, such as sadness or joy, but not the complex ones, such as regret, guilt, jealousy, nor love in its conventional form, although she is married to the love of her life and has two children. With his memories, Sociopath (Planet)seeks to promote empathy towards those who suffer from psychopathic and antisocial disorders, although it warns that the term that gives it its title is outdated and is confused with antisocial personality disorder. In the US, it is associated with serial killers, while in Spain “psychopath” is more used. According to the writer and journalist Álex Grijelmo, “sociopath” carries in English the idea of ​​“misfit”, a nuance that does not exist in Spanish. But as some psychologists understand, labels only indicate one direction and the essential thing is to understand the person as a whole. The interview takes place by videoconference on January 20, just after the return to the Oval Office of a president with characteristics similar to those described in the book. Ask. How do you define sociopath? Answer. Sociopathy, psychopathy, and antisocial personality disorder (ASD) are related, but different. The term sociopath, which is no longer used clinically, is now included within psychopathy, which is divided into primary (biologically determined, lacking social emotions such as guilt and empathy) and secondary (caused by the environment, capable of learning social emotions). Sociopathy is associated with secondary psychopathy. APD is a broader diagnosis that can encompass both sociopathy and psychopathy, although not all people with APD are sociopaths or psychopaths. Q. It is so complex that diagnoses can vary depending on the therapist. R. The challenge lies in the etiquette. Words like “psychopath” and “sociopath” are highly stigmatized. I heard one therapist suggest reclassifying sociopathy as “low affect disorder” to reduce stigma and better address the behaviors. A common misunderstanding is that sociopaths and psychopaths cannot feel, but we experience basic emotions, such as happiness and fear. The challenge lies in social emotions, such as love, empathy and compassion, which are learned, not intrinsic. Q. What did your doctoral studies teach you about the connection between sociopathy and anxiety? R. Primary psychopaths cannot experience social emotions or anxiety, while secondary psychopaths or sociopaths do feel anxiety. Treating anxiety can help sociopaths learn social emotions. In my case, the anxiety came from fear of rejection due to my lack of emotion. As a child, I hid my true self to fit in, but once I accepted that I didn’t need to be like everyone else, the anxiety disappeared. Although I still feel apathy, I no longer force emotions, and it is important to be surrounded by empathetic people. As a therapist, I learned that understanding others, even just intellectually, is key. Humanity is diverse, and mutual understanding benefits everyone, regardless of emotional capacity. Q. As if having full access to emotions could magically solve everything… R. Look, from my perspective it doesn’t sound that great (laughs). Q. So does treating anxiety to address sociopathy offer hope? R. Absolutely, I wrote my book to show that there is light at the end of the tunnel. Sociopathy exists on a spectrum, with most cases being mild to moderate. Focusing only on the extremes ignores these milder forms, which could escalate to more severe cases. It’s like only recognizing stage 4 cancer, ignoring stages 1, 2 and 3; Something similar happens with psychopathy. In our society emotions are often heightened; I encourage more acceptance and less anger.” Q. His difficulties in feeling emotions have not implied lacking a moral code, like when he chose “not to hurt anyone.” R. Correct. I am often asked what stops me from murdering someone if I feel no guilt or remorse, and my answer is: I hurt people all I want, but that amount is zero. It seems crazy to me that people believe that guilt and shame are necessary to prevent harm or crime, implying that human beings would always want to harm without these emotions. It is a self-destructive argument. Q. Is there hypocrisy in a society where people without diagnoses of mental disorders do not have to justify their bad actions? R. People with psychopathic and antisocial disorders are criticized for lacking empathy, but most neurotypical people deny it to them. Empathy is often learned through parenting, and a child who struggles in this regard usually doesn’t get much of it either. It is hypocritical to expect psychopaths to show empathy when it is not extended to them. Q. He says feeling accepted is liberating, but accepting those who don’t follow social norms is rare. R. Historically, those who are different are not easily accepted. My emotional difficulties don’t mean my feelings don’t matter. Psychopathy, sociopathy, and APD are often labeled as aggressive disorders, but we should focus on behavior, not emotions. I challenge the idea that children who lack social emotions like guilt are “bad.” They should learn to experience these emotions in a way that works for them, which could prevent destructive coping mechanisms. “Antisocial or narcissistic personalities thrive in professions where emotion can be an obstacle, such as politics.” Q. Unwanted loneliness has been his greatest suffering, but despite the difficulty in making friends, he managed to do so. How did he get it? R. When I accepted my differences and acted authentically, I found people who accepted me for who I am. This is true for anyone: self-acceptance leads to finding … Read more

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