We thought the marathon was heartbreaking. The largest medical follow-up to date has just settled the debate
When an amateur runner crosses the finish line after 42 kilometers, his body is on the limit, and so is his heart. This is something that can be seen in a simple analysis where it is seen how the levels of troponin T, one of the warning markers of a heart attack, and evident fatigue in the right ventricle. But in this case the question is obvious: Can doing a marathon kill us? The answer It’s no. This has been demonstrated by an exhaustive study published at the end of 2025 in JAMA Cardiology, which has pointed out that, despite the extreme stress on the heart in the short term, amateur marathon running does not cause long-term cardiac damage. To understand the magnitude of this discovery, we must return to the origin of fear and here recent works, such as those published in Frontiers in Physiology or studies on ultramarathon runners, have documented repeatedly what happens immediately after the race. What has been done. Logically, the effort of doing a marathon at a high level of effort induces morphological and biochemical ventricular changes. The heart here is subjected to a great overload of volume and pressure, releasing proteins that in a patient at rest in the emergency room would set off all the alarms for a possible heart attack. But to draw conclusions, the research has followed the same runners for ten years. The Be-MaGIC project. With this premise, the investigation was not born yesterday, but rather the team took advantage of the historical cohort of this project that originated in the 2009 Munich marathon. In this way, the researchers decided to follow 152 amateur male runners with an initial average age of 43 years. In this way, participants were evaluated before the marathon, after crossing the finish line, one day after, three days after and finally ten years later. To do this, state-of-the-art 3D echocardiography was used and also the analysis of cardiac biomarkers to determine how the ventricles function, which are ultimately the main pumps of the heart. The results. After all these years, studies indicated that, after completing the race, all cardiac function began to be greatly altered with increases in cardiac biomarkers. But this is something that was resolved in the following days until he reached the age of 10 with a completely perfect heart. No scarring of heart tissue, no premature heart failure. Everything is normal, despite the fact that after the race the stress to which he has been subjected is very high and can cause concern. What does this mean? The scientific study confirms that the human heart is an extraordinarily elastic machine. Here, right ventricular dysfunction and troponin release after running 42 kilometers should be interpreted as a transient physiological response to extreme exercise and not as permanent pathological damage. Of course, this doesn’t mean that marathon running is without acute risks, especially for people with underlying or undiagnosed heart conditions. However, for the average amateur runner who trains properly, the science is clear: crossing that finish line will exhaust your body, but it won’t mortgage the future of your heart. Images | Miguel Amutio Kenny Eliason In Xataka | Walking very fast seems the most effective way to lose fat: science knows that the key is to do it with an incline