We have found the Achilles heel of the most feared fungus in hospitals, and that already gives us hope

In the hospital environment there is a fungus that undoubtedly It is a real nightmare for modern healthcare systemssince it can put an entire hospital floor in check. We talk about the fungus Candida auris, which was first identified in 2009 and is undoubtedly a “superfungus” resistant to most common drugs and that it can spread quickly and be a silent epidemic that kills more and more human beings. Your weak point. Due to its aggressiveness, science has a clear objective: find your weak point to be able to develop a drug that allows us to destroy it. Now a group of researchers has published research in Communications Biology that changes the rules of the game: They have identified the exact genetic process that the fungus uses to survive inside the human body. And knowing its insides gives us options to destroy it. The iron problem. Like almost any living organism, this fungus needs iron to grow, replicate and cause damage. In the human body, iron is not “free” precisely as a defense system to prevent pathogens from using it against ourselves. Now science has seen that the fungus Candida auris It has a strategy to avoid this defense barrier that our body has. And the secret is in your genetics, specifically in some specific genes called XTCthat They literally act as ‘suction pumps’ which allows the fungus to capture iron even in the most hostile conditions. And this is the key. If iron is what feeds them, and we already know how they get the mineral from our own body… we already have the key to preventing them from consuming our own reserves. An unexpected ally. One of the biggest challenges in studying this fungus is that it has the ability to reproduce at high temperatures such as 37ºC. This makes it difficult to use traditional models to carry out studies, which until now were zebrafish, which want cold waters. To overcome this drawback, the research team used a rather innovative model: the killifish. A small fish that is capable of living in desert environments and tolerate temperatures of up to 37 °C, making it a perfect “living laboratory” to observe how the fungus behaves in real time within a vertebrate organism. Its importance. We must keep in mind that we are dealing with a pathogen that the WHO classifies as “critical priority”and that is why this research gives rise to creating drugs that attack the ‘suction’ system of fungi in order to defeat them. Plus, we already have something in our drug repository that we could use: iron chelators. An option that can ‘starve’ mushrooms, but has yet to be tried. In addition to this, the pathogens will be able to be identified much better, since there are strains of fungi that are much more aggressive because they capture a much greater amount of iron inside. The future. Although we have the focus about superbugs that can doom humanity, research must also focus on fungi that are developing resistance to specific treatments. In this way, finding a route that the fungus “cannot avoid” gives us, for the first time, a strategic advantage that we should not hesitate to use. Images | masakazu sasaki In Xataka | A viral video has “shown” all the bacteria in a drinks can. It’s more complex than it seems

A French people have to deal with an surprising incidence of ALS. The main suspect is a fungus

Amyotrophic lateral sclerosis, also known as ELA (ALS in English) is a disease capable of wreaking havoc in our nervous system. Today It has no cure And what we know about its origin is quite limited. Throughout decades of study, we have been discovering risk factors related to the appearance of this disorder but perhaps the strangest was detected a few years ago in a town in the French Alps. The unique case of Montchavin. A few years ago, a group of researchers discovered that the French people of Montchavin, located near the Alpine border with Italy, has a high incidence of ELA. After investigating the case, the team pointed out as possible culprit To a very concrete element of local gastronomy, the fungus Gyromitra gigasa type of false colmenilla or false morilla. ELA. The Amyotrophic lateral sclerosisknown among other names as Lou Gehrig’s disease, is a disease that affects neurons, both in our brain and spinal cord. It is a disease that is progressing until it ends the life of who suffers it. Today we do not know a cure, although there are treatments that relieve Some symptoms and increase the life expectancy of patients. The symptoms of this disease usually appear from the age of 50, although there are earlier cases, and They can start With problems walking, writing or speaking. The disease It generates the loss of muscle strength and coordination capacity, problems that extend to different muscle groups. Unknown cause. Today we have no accurate record of what mechanisms unleash this ailment, although we know Some risk factors correlated with their appearance. What we do know is that about 10% of cases are related to a genetic variant, and that the disease is more common among men than among women. Among the known risk factors are tobacco and exposure to certain environmental toxins. A higher prevalence has also been detected among people who did military service. The incidence of this disease It is between one and 2.6 annual cases per 100,000 inhabitants; with an approximate prevalence of about six cases per 100,000 per 100,000 people. An enigma in the French Alps. A few years ago, the cases of Montchavin unleashed the curiosity of the French neurologist Emmeline Lagrange. The health and its team accounted for 14 cases of ELA diagnosed between 1990 and 2018 linked to residents in this town, including migrants and people who had their second residence in Montchavin. Examining the case, the team did not find genetic factors that could justify the high incidence in the town. Although they found cases of smokers, they also ran into healthy habits in the group. Nor did they find clues of possible pollutants in land, air or water, or radon traces, a pollutant that could also be linked to this disease. From Pacific to France. As the journalist Terence Monmany narrates In an article For the medium Knowablethe team found a thread to throw on the remote island of Guam. On this island located in the archipelago of the Mariana Islands, in the Western Pacific, another team had detected a possible relationship between the consumption of potentially toxic seeds and the prevalence of neurological diseases (including ELA) among the natives. Although science is not settled in the causes of this epidemic, this hypothesis placed the consumption of food in the center of the debate. According to Detaine Monmanythe native chamorros treated these seeds with water to reduce their toxicity before their culinary preparation. This process would not be able to eliminate all toxins, giving rise to subsequent neurological damage. Gyromitra gigas. Something similar could be happening in Montchavin, not with seeds but with a mushroom. As the team observed, the cases could be drawn up to people linked to the collection and consumption of the fungus Gyromitra gigasa type of false morilla. It is a fungus in a toxic principle, but that, as in the case of Guam, can be treated to reduce its toxicity. In spite of this, the team maintains in its work that the incidence of the ELA in the town can be linked to its toxins and DNA lesions caused by these in the long term. The details of that study were published in 2021 In an article In the magazine Journal of the Neurological Sciences. A spurious relationship? In Xataka | I am a journalist, I have ela and I can’t move anything from my body except my eyes … So I write articles with my pupils Image | Henk Monster / Alexey Laa

In ‘The Last of Us’ cordyceps is a zombie fungus. In Nepal it is a sexual fungus so exclusive that people die to achieve it

In 2006, The BBC Earth serieswith David Attenborough narrating the chilling sequence, he first revealed to the world of What was capable of a parasite fungus in the body of a creature. We had never been participants in something like that, and the guest that carried the disoriented ant of the colony was going to turn the scene into television history. Years later, the clip with the spores of the parasite fungus cordyceps served as inspiration for the game ‘The Last of Us’, and the subsequent series. In the real world, Cordyceps is also dangerous. A fungus wrapped in myth. The story I told Bloomberg in a report. In the extreme heights of the Himalayas, The cordyceps sinensisknown as “Yartsa Gunbu” in Tibetan or “Caterpillar Fungus”, has been used for centuries in traditional Asian medicine. Its peculiar origin, growing like a parasite inside the ghost moth larvaeand his reputation as a powerful aphrodisiac, they have made it one of the most coveted natural products in the world, reaching exorbitant prices that can reach up to $ 136,000 per pound in Chinese markets. Popularly known as the “Viagra del Himalaya”, the fungus has generated a whole multimillionary industry behind With a growing global demand, especially in China, South Korea and Japan, where it is a symbol of status and prestige. Booming market of falsifications. While in the West the cordyceps can be found in cheap supplements in stores like Amazon, most of these products do not contain the real fungus, but synthetic versions or similar species without the alleged desired effects. In fact, Stanford University research estimates that The global cordyceps industry moves up to 11 billion dollars annuallyalthough much of this trade is based on imitations. According to German mycologist Daniel Winklerwho has spent two decades studying the fungus in the Tibet, authentic products are rare and are sold almost exclusively in Asia at prohibitive prices. Nepal: an economy around the fungus. In Katmandú markets, each store seems to sell the precious fungus, with merchants such as KC Bastola, who offers different levels of quality with prices ranging between $ 10 per piece and $ 4,000 per poundstill relatively low values ​​compared to the final price after the passage of intermediaries. As we said, Here the business is dominated by Chinese buyers, Many of them identifiable for their luxury clothing, which acquire large amounts of cordyceps to resell them in their country of origin, where the government imposes strict regulations on their harvest and trade. We talk about a trade that has generated an economic boom in rural communities of Nepal and Tibet, where Collectors like Tek Bhadur Budha manage to earn up to $ 15,000 a yearenough money to keep their families and send their children to study in the capital. The danger: more deaths than in Everest. Cordyceps sinensis collection It is an extremely dangerous job. The reason? It is carried out in rugged land, more than 4,500 meters altitude, where collectors spend whole days looking for tiny fungi, often on knees and with temperatures below zero. Every spring, entire villages leave their homes and set up improvised camps on the mountaineven closing schools for children and adolescents to participate in the collection. A fact to put it in context: in recent years, more people have died hunting Yartsa than climbing Mount Everest, victims of extreme cold, avalanches, sudden floods and violent clashes between collectors. Everything is worth. For its part, the Dalai Lama has described the cordyceps industry as a crisis for Buddhist culture because its high value has caused violence, exploitation and corruption in the region. Criminal gangs have murdered collectors and have appropriated harvest territorieswhile the use of child labor is an extended practice, with minors dedicated to looking for fungi in extreme conditions. In addition, the lack of regulation allows intermediaries to buy the fungus at very low prices, leaving collectors at a disadvantage against a market dominated by large merchants. Is it really an aphrodisiac? Despite their reputation as sexual stimulating, scientific studies They have found little conclusive evidence that cordyceps has a direct impact on libido. An eight -week study only identified that Consumers felt more energy, but without significant improvements in sexual desire. It happens that the placebo effect and cultural beliefs play a key role in their consumption. According to anthropologist Tawni Tidwellalthough the fungus does not improve its own sexual desire, You have seen notable results in peoplewith men reporting stronger and more lasting erections, and women affirming an increase in their sensitivity. On the other sidewalk, Tashi Tsering doctor, defender of cordyceps, argues that The fungus harmonizes the five cosmic elements (Earth, fire, water, air and space) and that its effectiveness lies in an energy balance rather than in a direct biochemical action. That said, its consumption is not exempt from side effects. In fact, the author of the Bloomberg report said that after drinking a cup of yartsa tea experienced an intense gastrointestinal reaction. The ecological impact of the fungus. It is another cordyceps problems. The growing fungus market has generated an environmental crisis in the Himalayas. The International Union for the Conservation of Nature (IUCN) has cataloged it as a species vulnerable to extinctiongiven that Demand has led to overexploitation which exceeds the natural capacity of regeneration of the ecosystem. More than 130 tons of cordyceps per year are collectedcausing soil erosion, abnormalities in snow cycles and changes in ecological balance. In fact, experts warn that if the situation continues, the wild populations of the fungus could disappear in a few decades. Illegal regulation and traffic. Unlike Nepal, where cordyceps collection follows a more open model, China strictly regulates its harvest and sale. This results in Many Chinese merchants cross the border illegally to acquire large quantities of the fungus in Nepal and then traffic it back to China inside suitcases or vehicles. According to Rajendra BajagainMember of the Parliament of Nepal, this activity is out of control, with foreign buyers promoting a black market … Read more

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