mice that do not fattens although they consume a fat diet

What makes us fat? The question is simple, but the answer is not. We could simply say that it is a mathematical issue, calories that enter through calories that burn, but it would be to simplify the matter too much, forgetting that each body metabolizes food differently and that different foods and combinations of food can lead to slightly different results. A simple protein. The deficiency of a simple protein, CD44, Avoid in an experiment that a group of mice will gain weight even being subjected to a high diet in fat. The team responsible for the experiment tried to inquire into the role that this protein plays in metabolic health and obesity, a role, according to the results, of great importance. “We had previously pointed out that the deficiency of CD44 suppressed neuroinflamation. Give Metabolic, ”he explained In a press release Cheng Sun, co -author of the study. CD44. But what exactly is this protein and what do we know about its function in the body? CD44 is one Transmembrane proteina protein located in the cell membrane that crosses this layer that covers the cell. As explained by the team itself, this protein “plays an essential role in transcending extracellular stimuli within intracellular signal waterfalls”, thus contributes to metabolic regulation. This protein is also of special importance for cancer cells. Closing the step. The team genetically modified a group of mice to force the lack of this protein. In doing so, they observed that, even when they were provided with a high fat diet, the modified mice did not fat while the control population (not modified mice) did gain weight until developing obesity. The team responsible for the study He also points out The possible mechanism behind this relationship between lack of protein and thinness. They explain that this relationship can be attributed to the suppression of the so -called adipogenesis in the white adipose tissue. That is, the creation of the cells responsible for storing precisely where we accumulate more is avoided. The details of the study were published In an article In the magazine The American Journal of Pathology. A new route. The team compares this path for weight loss with the one used by drugs such as Ozempicthe so-called LPG-1 (since its competence active emulates the effects of the peptide similar to type-1 glucagon). Very different routes in each case. As detailed by the team itself, the agonists of the GLP-1 receptors regulate the appetite and the metabolism of the glucose; Inhibition of the CD44 protein, meanwhile, acts preventing the formation of fat cells. This difference, they emphasize, implies that protein inhibitors could be used as accessories to treatments such as Ozempic when weight loss is sought. In Xataka | The Greek yogurt has conquered the supermarket yogurts. All thanks to the magic word: protein Image | EMW / I Yunmai

What’s behind the fever to cool food so that it fattens less

Something is changing in the kitchens, and I’m not talking about The arrival of the Cosori. Rather, those small, apparently insignificant decisions, which take shape between common foods. It is no longer enough to choose between integral or white rice, between mother’s bread or industrial slices. Now, the debate moves to temperature: have you cooled rice? Have you saved that pizza to reheat tomorrow? What looks like a more domestic mania is, in fact, part of a silent revolution driven from social networks and backed – at least in part – by science: that of resistant starch. From networks to the large intestine. The story begins in social networks and other corners of the influencer universe. They appear Videos cooling and overheating rice bowls and even ensuring that a pizza involved in the fridge becomes “healthy”. Everything is summarized in a promise: less glucose, less calories, more health. Resistant starch? Let’s enter into matter so that it can be understood well. The starch It is a chain of molecules of glucose that some plants store as a source of energy. There are different ways of organizing those chains, and according to their structure – more or less accessible to our digestive enzymes – the body may digest it or not. When foods rich in starch are cooked (such as pasta, potatoes or rice), heat causes a process called gelatinization: chains are messy and become more digestible. But if they get cooled later, part of those chains are reorganized in a new, more compact and difficult to break for our enzymes. That process is called retrogradation, and the resulting product is resistant starch. This “reborn” starch reaches the large intestine without being absorbed. There it is fermented by the microbiota, producing beneficial compounds such as butyrate, a fundamental fatty acid for intestinal health, According to the Commonwealth Scientific and Industrial Research Organization (CSIRO). Butirate not only feeds the intestine cells, it also protects the mucosa and can help prevent diseases such as colon cancer. Is it really beneficial? Science partially supports enthusiasm. According to Cleveland Clinicresistant starch behaves similar to fiber: it helps maintain intestinal health, improves the composition of the microbiota and helps to regulate blood glucose. You have to differentiate in four types: Type 1: Present in legumes, whole grains and seeds. Its cell structure makes it inaccessible during digestion. Type 2: It is found in raw foods such as green banana or potato without cooking. Type 3: It is the one that forms when cooking and then cooling foods rich in starch (such as rice, pasta, bread or potato). Type 4: It is a chemically modified starch, present in processed products. According to A meta -analysis cited in Scientedirectthese effects are more notable in types 1 and 2 of resistant starch (those present naturally in green legumes and bananas). Type 3, which is formed by cooling cooked foods, also seems to have benefits, although somewhat more modest. It is not the philosopher’s diet. From Cleveland Clinic They have explained That resistant starch acts similarly to the fiber: it improves the microbiota, it can help regulate blood sugar and have positive effects on the immune system. However, There is no solid evidence that alone it helps to lose weight or reduce appetite, although it may have a light satious effect. There may be risks. The part that does not always appear in the networks of networks is that cooling foods such as rice or potato can have microbiological risks if it is not done correctly. Specifically, the Bacillus cereus, a bacterium that survives cooking and produces toxins in food that spend a lot of time at room temperature after being cooked. In a report from El País They have warned that the heating and cooling cycles – just those promoted to generate resistant starch – are perfect for this bacteria to activate. Basic recommendations: Cools food in less than an hour. Store it in the fridge and consume it at 24-48 hours. Reheat only once already high temperature. Never leave it several hours at room temperature. In search of a balance. Is it worth eating more resistant starch? Science says yes, especially when it comes from integral foods, legumes, firm bananas or well -manipulated tubers. It has effects similar to fiber, helps microbiota and can be part of healthy eating. Will you magically convert a pizza into salad? No. like We have explained in this mediumthe real effect on health is minimal if it is not accompanied by a context of healthy habits. The total diet and your lifestyle continue to weigh much more than a cycle of cold and heat on a plate of rice. It may not be a revolution, but a track of where part of the current interest in food moves: look for more fiber, more microbiota, more glycemic control … and less ultrazúcar disguised. The resistant starch, by itself, will not convert ultraprocessed dishes into healthy or to replace a balanced diet, but can add – like so many other small decisions – to a more conscious way to eat. Image | Unspash Xataka | The spicy is proof that we can fight heat with “fire”

It turns out that the myth that marriage fattens is true. But only for men

There is a preconceived and quite widespread idea that relates marriage to accumulating kilos. Well now a group of researchers has contrasted that this prejudice with respect to the marriage union is correct. Or at least correct. An unequal effect. A new study has observed that the risk of obesity increases significantly in men after marriage. It triples, in fact. The same study, however, did not find a significant change in this probability in the case of women. Of course, the risk of developing overweight did increase in both groups. The results must still be interpreted with some caution because the details of the study have not yet passed the scrutiny of peer review and publication in a scientific journal. Those responsible for the work will be presented by this spring in the 32nd European Congress on Obesity that will be held in Malaga in May. Why do we get fat? The question of why we get fat can have many answers. The simplest is that our body absorbs more calories than it burns, so stores energy in the form of fat. However, this is only part of the story: there are many genetic, environmental or socioeconomic factors that we know are, the less, correlated with our risk of developing overweight or obesity throughout our lives. Little by little we verify that marriage is one of them. 3.2 times higher risk. The study indicated that marriage multiplied by 3.2 the risk of men to develop obesity, while the effect of this union was not significant in the case of women. The risk analysis to develop overweight showed a less marked difference. The team responsible for the study observed A 62% increase in the risk of overweight in the case of men. A risk that in the case of women stayed at 39%. Multiple factors. The study analyzed other factors linked to this relationship, which showed other connections of interest. It was thus observed that some factors affected the risk of obesity in the case of women. For example, depression caused the risk to be folded, while lack of health in terms of health also increased risk in women by 43%. This type of factors and interconnections helps us understand what is happening behind the data. Even so, the hypotheses are diverse (and complementary). For example, Less physical activity by men And social pressure in the case of women can help us understand the unequal phenomenon. “Research also suggests that men may have greater propensity to gain weight after marriage due to factors such as an increase in portions, social meals, and a decrease in physical activity; while women may remain more aware of weight due to social pressures ” He pointed to the British newspaper The Guardian Katharine Jenner, director of Obesity Health Alliance. Also age of age. Another important factor to take into account was that of age, as it could foresee. The study showed that age affected the probability of developing overweight and obesity, and that in this case the effect was greater in women than in men. Thus, for example, the risk of obesity increased by 3% per year in the case of men and 4% per year in the case of women. Understanding the context. Understanding the effect of factors such as marriage can help us develop more effective policies to address obesity and overweight, with the ultimate goal of addressing public health problems such as the increase in some non -transmissible diseases for which obesity and overweight are risk factors. In Xataka | We have a way to improve the effectiveness of treatments such as Ozempic to lose weight: deceive metabolism Image | Jeremy Wong

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