decades

Alzheimer’s leaves its mark decades before showing its face:; keeping vitamin D at bay is already a promising shield

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Alzheimer’s and other forms of dementia remain one of the most complex medical puzzles of our era, standing out above all for the absence of treatments that completely stop the disease or even reverse it. But science continues to advance and has now focused on a preventive factor that could be in our hands from a young age: vitamin D. It keeps moving forward. The main study that has sparked interest was published at the beginning of this month of April in the magazine Neurology. And the objective of this was none other than to shed light on how our brain behaves decades before the classic symptoms of dementia appear. To get here, a total of 793 participants from the renowned Framingham Heart Study with an average age of 39 years were monitored. From here, the serum vitamin D of the patients began to be measured between 2002 and 2005, and then, at the age of 16, they underwent different scans to check the state of the brain. What was seen. In conclusion, the study pointed out that maintaining higher levels of vitamin D, greater than 30 nanograms per mL, during the ages of 30 to 40 is associated with less subsequent accumulation of the tau protein in the brain. Because it matters. The relevance of this discovery is crucial and to understand it, you just have to know that Alzheimer’s occurs because two factors mainly come together: Beta-amyloid protein plaques, which accumulate outside neurons. Neurofibrillary tangles of tau protein, which form within the brain cells themselves and are closely linked to neuronal death and cognitive decline. In this way, the effort of science right now is focused above all on blocking the formation of beta-amyloid plaques around neurons or preventing the tau protein from accumulating in our neurons. Although it is something really complicated. There is a nuance. Interestingly, the study found no association between midlife vitamin D levels and beta-amyloid accumulation. The protective effect is limited exclusively to the tau protein, especially in the brain regions where Alzheimer’s usually strikes its first blows. This is good news, as it narrows down the biological mechanisms involved and suggests that vitamin D could play a specific role in the pathways that regulate how tau is produced or eliminated over the years. There is small print. As they warn in the press release itself, this is a simple observational study. This means that it is true that people with higher vitamin D in middle age accumulated less tau protein, but the study cannot categorically state that vitamin D destroys tau protein on its own. Furthermore, the authors of the study themselves are categorical: this finding is not a medical prescription. There is no current evidence to justify that massively supplementing with vitamin D pills at age 40 will protect the brain against dementia. This simply paves the way for future research to truly test this relationship in a clinical trial and lead to new treatments. Images | catalyststuff freepik In Xataka | More than half of the population in Spain has a vitamin D deficiency. Now a study questions the benefits of supplementation

two decades later, his worst nightmare is underselling it

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Just open anyone’s closet Millennial to find them, whether worn, scribbled or with the sole on the verge of collapse. The Converse Chuck Taylor All Star have been much more than a shoe: they were our—this editor includes—unconditional companion that survived all our aesthetic phasesfrom the fever skater in the style of Avril Lavigne until it becomes the essential everyday basic for going to the office. However, in recent years we have observed that this situation is no longer the case. Although fashion magazines try to convince us that they are back, we know that both the street and, now, the income statement tell a completely different story. The symbol of our “rebellious” youth is sinking. The financial free fall. The numbers don’t lie, and the market verdict is being relentless. According to a report by Bloombergthe Converse brand is currently in free fall, with its revenue heading dramatically toward its lowest level in 15 years. The magnitude of the disaster breaks down a financial drain: the brand has had three disastrous quarterswith consecutive drops in income of 27% in the first quarter, 30% in the second and a brutal collapse of 35% in the third quarter, remaining at a meager 264 million dollars due to the general weakness in all global territories. A huge contrast with its matrix. In October 2024, Elliott Hill took over as CEO of Nike and, from that moment on, the sports giant has shown signs of improvement, especially in the United States and in the wholesale market. However, Converse’s problems have intensified. In the November quarter, the Boston-based brand accounted for less than 3% of Nike’s $12.4 billion in total revenue, becoming the biggest drag on the company’s resurgence. But how could it happen? That is, how has such an iconic sneaker lost public favor in this way? (It is also true that the Millennials We are a bit egocentric. The answer lies in a mixture of immobility and lack of technical vision. Laurent Vasilescu, analyst at BNP Paribas cited by Bloombergis blunt about this: “Converse has lost ground over the years because it has not provided innovations. There was an excessive dependence on the Chuck Taylor model.” The brand rested on the laurels of its classic design. When they tried to modernize it—with the launch of the line chuck IIwhich incorporated Nike foam technology to make them more comfortable—the experiment turned out to be a resounding commercial failure. The market has changed drastically. As pointed out Seeking Alpha, Converse has come face to face with a consumer that now demands technical innovation, losing the battle to newer, performance-oriented brands such as On and Hoka. To this we must add the historical irony that Converse was not always a street shoe; In the 50s and 60s, it dominated more than 60% of the basketball market, shoeing legends and starring in the 80s. the iconic rivalry between Magic Johnson and Larry Bird with his Weapon model. Paradoxically, it was Nike itself that ended its hegemony on the fields by signing Michael Jordan. After losing its sporting throne, Converse was relegated to casual fashion, a terrain that is now also crumbling. Are we facing the end of an era? Faced with this crisis, Nike’s initial response in Oregon has been to take out the scissors. According to Bloombergthe company reduced Converse’s workforce, restructured its organization and took a severe 44% cut in marketing expenses during the fiscal second quarter. Despite this, Elliott Hill declared to Bloomberg TV in Milan: “I have heard the rumors (…) But we are committed to the Converse brand.” The rescue plan involves a desperate attempt to recover the lost glory on the trading floor. In fact, Converse has once again opted for professional basketballlaunching $130 sneakers in collaboration with Shai Gilgeous-Alexander, the reigning NBA MVP, in September. A little hope. So if the resuscitation attempt fails, it already exists a pretty clear option: Authentic Brands Group (ABG). This brand management giant, led by Jamie Salter, has a long history of buying struggling historic companies to squeeze sales through licensing and operating agreements. They already did it with Reebok (purchased from Adidas in 2022 for 2.5 billion, managing to increase their retail sales by 50%), and they also control Champion, Guess and Forever 21. According to BloombergABG has expressed a long-standing interest in acquiring Converse if Nike finally decides to hang up the “For Sale” sign. The reality of the street. There is a fascinating fracture between what the fashion industry dictates and what consumers actually buy. On the one hand, fashion headlines have been since last year announcing a “quiet return” of Converse, applauding like celebrities like Alexa Chung or Charli XCX wear the classics again high-tops in campaigns or fashion weeks. They speak of an abandonment of quiet luxury in favor of nostalgia. However, the overwhelming financial data of Bloomberg show that this supposed rebirth It’s an Instagram mirage. The generation millennialwhich massively adopted this shoe in 2008, has changed its priorities to an ergonomic model, support and comfort. The Converse look very good in the photos of street stylebut they are no longer profitable on a day-to-day basis. We have gotten older. Nike bought Converse in 2003 for $305 million, rescuing it from a painful bankruptcy filing. Today, more than two decades later, history threatens to repeat itself. Whether it achieves a sales miracle thanks to the NBA MVP or ends up being devoured by Authentic Brands Group’s mass licensing model, one thing is clear: Converse’s golden era is over. For the millennial generation, seeing their iconic sneaker fight for its survival is a relentless reminder of the passage of time. Converse will continue to exist, probably in the back of our closet or as a product of licensed nostalgia, but the incontestable symbol of our cultural dominance is fading forever. Image | PickPik Xataka | We went out for a 20-kilometer run with a bag of liquid cream in our backpack: now we have our own butter

In 1994, a programmer created a “temporary” interface for Windows. Three decades later he is still with us

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Windows is one step away from turning 40 years old. The first version of the operating system appeared in November 1985and since then it has not stopped evolving. However, Microsoft tends to take a long time to update some components of its products. With Windows 10, for example, it released a renewed user interface, but it was not until years after its launch that it began to get rid of some icons from the Windows 95 era. Now, in Windows 11is renewing programs like paint and Notepad. Regardless of how modern Windows 11 may feel, and all the new features that come with its updates, the system still retains some elements that we could classify as historical. Among them we find the utility to format disks. WINDOWS 10: 9 VERY USEFUL and LITTLE KNOWN TRICKS Currently, if you wanted to format a storage drive from Windows 11 you would find a pop-up window practically identical to the one you could find decades ago. In fact, we know exactly who created it. The format drives dialog in Windows 10 A former Microsoft programmer named Dave Plummer recently shared an some interesting facts about this part of the operating system. The now entrepreneur says he created the Format dialog box one rainy morning from the end of 1994. He says that they were migrating millions of lines of user interface code from Windows 95 to Windows NT, and that the formatting section was very different between systems, so it was necessary to create a new user interface. And Plummer took on this task. The programmer did not think of doing a definitive job, but of providing a temporary solution with the help of a sheet, a pen, Visual C++ 2.0 and the Resource Editor. “It wasn’t elegant, but it would do until the elegant user interface arrived,” he says in the message. Plummer also set the 32GB limit for the format of FAT volumes that morning. It is curious, because FAT is capable of working with larger volumes, although to create volumes with this capacity it is necessary to use the command line. The disk formatting utility interface appeared in Windows NT-based operating systems, such as Windows 2000 and Windows XPand it has been with us ever since. Throughout this time it has basically been a temporary solution created in 1994. Images | Windows | Genbeta In Xataka | Intel is hunting and capturing new customers. His next goal: convince Elon Musk and make chips for Tesla

The Tax Agency has not made the income tax return manual accessible for decades. A Valencian man did it in three hours

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“Javier, has the program PADRE come out yet?” Every year, at the end of March, my father—not to be confused with my FATHER—asked me the same question, because I was like an AI alerting him that he could finally get down to it. the income tax return every year. For him that was not just an obligation. I would say it was a hobby. Almost a passion. Something to which he dedicated hours and hours in his office armed with his pens, his tight handwriting, his calculator and of course with the Nobel package next to it. He is no longer here, but if I have not inherited something from him, it is that passion for filing income tax returns. In fact, I have never done it, perhaps because as I saw that he dedicated so many hours and effort to making it perfect, that caused me some trauma. “Ugh, this costs too much,” I told myself then and I continue to tell myself now. And here I am, with a reverential fear of completing that task, which I end up entrusting to a manager because time, they say, is money. And yet, it is a small outstanding debt that I have. Last year I tried to try it, and this year I told myself that maybe with the help of some local AI model (because of privacy) I should try it again. But while I was thinking about it, these days the practical manual of Income 2025and one person decided to do something very interesting with that information: he turned it into something useful. This is how the LaRenta.es Open Source project emerged This manual, no matter how complete and detailed it may be, has a problem: it is very inaccessible. The information is there, but neither the wording nor the structure or its organization make it a particularly useful document for most users. That’s where it came into action. Paul March (@paumrch), a public administration worker who lives in Valencia and who, at 31 years old, has a profile completely aligned with the so-called civic technology. Although his training is not technical, he is a very restless self-taught person who has been “tinkering” with all kinds of personal technological projects for more than 15 years. And the latter has become especially popular. We have had the opportunity to speak with Pau and he told us that by working in public administration and being interested in the application of technology to his field, “I have always been interested in the issue of digitalization of the administration because I know it and I know the room for improvement there is and I am convinced that citizens need that improvement.” When the Income 2025 practical manual appeared, he realized that he could try to do something with it. With the experience of previous projects and the new AI tools that he had been using for months, he got the ball rolling. In just three hours, he confesses, he created LaRenta.esa web service that allows any user Know what state and regional deductions you can take advantage of in this statement. The first question of the questionnaire is important: where we pay personal income tax. The deductions to which we may be entitled depend on this parameter. To do this, it has created a very simple system in which, from a small questionnaire that takes two minutes to complete, we can obtain information about these deductions. The process is reduced to going through seven stages of this questionnaire with a few questions, from which it is possible to obtain a final summary with deductions to which we may end up being entitled. And in each of them, we will have an indicator to know what percentage of the total of each deduction we may be entitled to, as well as detailed information about each particular deduction. In these details, the information present in the 2025 income manual is used more clearly and directly, but although the language is still somewhat harsh, at least in this project only that which is directly related to that deduction is shown in a more readable format. We are therefore faced with a project that is not intended at all to prepare your income tax return, but rather to at least provide the information that exists is more accessible and easier to understand. And as March says, it is far from being a perfect project, but it certainly shows that all that information offered by the public administration can be converted into something even more useful in a relatively simple way. From idea to application in three hours These days this entrepreneur explained the process of creating this webapp in an article posted on his Twitter account (X), and as I said there, the cycle was surprisingly simple. AI was his companion throughout the project, and he took advantage of his experience with previous projects to then take advantage of several tools: The interface design was carried out with the help of GoogleStitch The programming was done with the plugin Claude Code in Visual Studio Code. He used Opus 4.6 to plan the entire project, and Sonnet 4.6 to program it, although for some basic tasks he indicates that he also used Anthropic’s basic model, Haiku. He did it all on March 19, right during the Cremá, the big day of the Fallas in his city, Valencia. The project absorbed him so much that he didn’t even enjoy the party and he spent that afternoon and part of the night polishing the errors he was detecting. The result, as can be seen on LaRenta.es, is a fully functional, fast, clear and practical web application. Not only that: it is totally private. Pau explains that no data is saved except for the email if a user wants the summary PDF report to be sent to them. The potential of civic technology When the project was finished, Pau decided post a message to share it through your Twitter … Read more

Spain has been ignoring dozens of products that it sells daily in its supermarkets for decades. But that just ended

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You may have read or heard it somewhere: “goodbye to turkey ham and stuffed olives.” And what a joke, can you imagine a world without anchovy-flavored olives? Having to live only on ham or chicken breast? Luckily, you don’t have to imagine it. They don’t disappear. What the Royal Decree does has unleashed All this controversy is something a little more complicated: putting in order the enormous food mess that has been growing for decades in Spanish pantries. What food mess? On February 27 Royal Decree 142/2026 was published that seeks to modify (or repeal) more than a dozen food quality provisions. It seems somewhat minor, but some of which (such as the cookie regulations) are more than 40 years old. The interesting thing, however, is that this new legislation removes from legal limbo numerous products that have not been ‘thought of’ at a regulatory level for many years. In that sense, the decree affects dozens of daily consumer products, but it does not affect them in the sense that ‘they are going to change’: it affects them in the sense that now the rules are going to be clearer. The case of turkey ham and stuffed olives are paradigmatic: the former now has a clear definition and the latter will have the obligation to specify the characteristics of the filling. But what is interesting is not what is important. The important thing, clearly, is the inclusion of gluten-free bread in the bread quality standard. Not only is it a historic demand of the celiac community, but it closes a very tough debate at a regulatory and fiscal level. Until now, at a technical level, the standard did not contemplate that bread made with gluten-free flour could be called bread. This ‘nonsense’ made celiacs They will pay more VAT than they would pay on normal breadbut it’s already over. Something similar happened with horchata without added sugar, the clarification of cider, the types of sangria or the acidity of vinegars. What does disappear. The bologna mortadellawhich until now was a category and which will now have to be called something else to avoid confusion with the designation of origin of the true Bologna mortadella. The central issue is that the agri-food industry has changed a lot. And as usual, the legislation has been dragging its feet, generating piecemeal regulations and creating completely inexplicable holes. So yes, we have taken a step forward. And without having to give up even the turkey ham and stuffed olives. Image | Xavi Cabrera In Xataka | This is how ultra-processed foods have been invading our diet: the evolution of three decades in a single graph

the result of decades of veto by the US and Japan

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China has just become the first country in the world to mass produce T1200 grade carbon fiber, the strongest synthetic material ever manufactured on an industrial scale. The milestone is led by the state group China National Building Material Group (CNBM), which presented it on March 11 at JEC World, the most important composite materials fair in the sector, held in Paris. We tell you all the details. What exactly is the T1200. In the world of advanced materials, the number that accompanies the T is a tensile strength rating. The higher the number, the stronger the fiber. T1200 has a resistance greater than 8 gigapascals (GPa), ten times more than conventional steel, and yet its diameter is ten times smaller than that of a human hair. Chinese media CCTV exposed the example that a rope less than two millimeters thick, made from 120,000 twisted T1200 filaments, is capable of towing a bus with 54 adults on board. And it weighs a quarter as much as steel. dhe laboratory to the factory. Zhou Yuxian, president of CNBM, counted that it has taken the country about 20 years to move from its research and development to mass production. The plant has a projected capacity of about 100 tons per year. Compared to that of Toray Industries, the Japanese company that leads the global market with 29,100 tons per year, it is laughable. But be careful, Toray announced in 2023 that it had developed its own T1200, also with 8 GPa resistance, but to date they have not offered details about a supposed mass production. China has beaten them to it. Mbeyond engineering. Industrial carbon fiber is a material that can be used for endless applications: from civil (aeronautics, electric vehicles, hydrogen storage, drones, medical devices, elite sports equipment) to military (fighter aircraft, missiles, satellites, fuselage structures). Precisely for this reason, Japan and the United States They have been strictly controlling their exports for decades through mechanisms such as the Wassenaar Agreement. China, which for years has depended on imports or has been forced to obtain the material through alternative means, just remove that dependency. The same has happened with semiconductors, since the foreign blockade has served to amplify their technological self-sufficiency. How China has accelerated in just a few years. Toray launched the T300 in 1971 and took 43 years to introduce the T1100. China didn’t have its own T300 until 2008. However, in just over a decade it has climbed from the T300 to the T1200, a cadence that the entire industry is watching closely. The key has been a model that China has already demonstrated with previous grades of this material: combining state capital, university research and industrial capacity in the same ecosystem, with continuous improvement cycles until reaching mass production. Who else competes in this race. The global carbon fiber market is an oligopoly with few relevant players. Mitsubishi Chemical (Japan) advertisement in December that it plans to double its production capacity in Japan and the United States between now and 2027 for sectors such as aeronautics and supercars. The South Korean Hyosung Advanced Materials aims to reach 24,000 tons per year in 2028. On the other side of the globe, Hexcel, an American composite materials company, defines itself as the world’s largest producer of aerospace carbon fiber and the main supplier for United States military programs. But the geographical trend has already changed. And according to the report Future Markets’ Global Carbon Fiber Market published in February, Asia-Pacific has surpassed North America and Europe as the world’s largest consuming region. Cover image | CCTV In Xataka | Japan has a rare earth megadeposit: 700 years of consumption to challenge China

Iceland, Norway and Switzerland have been boasting independence from the EU for decades. Global chaos is about to change everything

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The war between the United States, Israel and Iran is shaking the foundations of the historic independence of the nations that make up the European Free Trade Association (EFTA or EFTA). Faced with an increasingly volatile geopolitical panorama, Iceland, Norway and Switzerland find themselves at a crossroads and look, each at their own pace, towards the European Union in search of refuge. The question that now haunts European parliaments is no longer just political, but purely industrial: are they willing to sacrifice parts of their sovereignty in exchange for the protection and stability that Brussels offers? As explained to the newspaper Five Days Sophie Altermatt, economist at Julius Baer, ​​these countries face external pressures from increasingly interventionist superpowers. The United States has become a much less predictable ally on trade and security, while China’s growing ambitions endanger European industrial competitiveness and create vulnerabilities in supply chains. The rhetoric of US President Donald Trump, who has even suggested his intention to annex Greenland, has acted as a powerful catalyst for this change in mentality. As the magazine warns The Spectatorquoting a maxim from Mark Carney: “If you’re not at the table, you’re on the menu.” The return of hard power politics is forcing middle powers to reevaluate their place in the world. From the European side, the door is open. As detailed by the Icelandic public broadcaster RÚVEU Enlargement Commissioner Marta Kos has stressed that the current geopolitical context is fundamentally different from the past and that EU membership offers “an anchor in a bloc based on values, prosperity and security.” Are we facing a real approach? Moving towards greater integration implies sitting at the table where decisions are made, but also assuming a clash of sovereignties. Ine Marie Eriksen Søreide, leader of the Norwegian Conservative Party, acknowledged in a parliamentary debate collected by Five Days that remaining outside the Union generates enormous vulnerabilities, since their country remains “on the margins of everything we want to enter into.” However, the price of admission is high. Political analyst Thomas Vermes explains in the Norwegian middle ABC Nyheter that the EU is transforming towards a federation where supranational organizations assume more and more authority. Entering means submitting to decisions by qualified majority – where large countries have more demographic weight – and growing pressure to eliminate the right to veto on key issues. In addition, it would imply assuming joint economic burdens, such as the common debt of 90 billion euros contracted to help Ukraine. In fact, the possible entry of Ukraine would radically transform the bloc’s economy. According to the same Norwegian mediathe incorporation of the 41 million hectares of Ukrainian agricultural land would flood the markets and force rural aid to be restructured. Three countries, three different rhythms The answer to this dilemma varies drastically depending on the resources each nation brings to the table. Iceland: The direct path and the referendum in sight The Icelandic government has stepped on the accelerator and passed a resolution to hold a referendum on August 29, 2026 on resuming EU membership, a measure supported by 57% of the population. Iceland would provide the EU with a vital logistics position in the emerging Arctic trade routes and strategic supply: already is the fourth largest supplier of aluminum of the block, material that accounts for more than half of its exports to Europe. Nevertheless, as reported RÚVthe Minister of Foreign Affairs, Þorgerður Katrín Gunnarsdóttir, has drawn a non-negotiable red line: she will not sign any agreement that involves ceding control over the island’s precious natural resources to the EU. Norway: The fractured debate Although the country rejected joining the EU in 1972 and 1994, the debate has been resurrected. According to The Spectatorthe conservative party (Høyre), now led by the determinedly pro-European Ine Eriksen Søreide, is “clearly a yes party.” Polls show an increase in support for accession, rising from 27% in 2023 to 41% in 2025. However, the current Labor government of Prime Minister Jonas Gahr Støre is strongly opposed. Despite not being a member, Norway is Europe’s absolute energy guarantor after the invasion of Ukraine: it supplies 51.8% of the pipeline gas and 14.6% of the crude oil consumed by the EU. Precisely for this, the internal opposition is fierce. Columnist Hans Christian Hansen warns in the financial journal Finansavisen that the EU is losing technological ground to the US and Asia. According to Hansen, while the US uses energy to attract industry, the EU uses it to “self-regulate with increasing rigor” and promote projects of uncertain profitability such as offshore wind. The question he asks his compatriots is brutal: “Do we want to link our energy policy, our industry and our future to a team that is already losing?” Switzerland: The pragmatic path and bilateral agreements Unlike the Nordics, Switzerland does not contemplate full accession so as not to compromise its historical neutrality, but it is making progress in its economic and technological integration. President Ursula von der Leyen and Swiss President Guy Parmelin They signed the “Bilateral III” package. This framework modernizes agreements on transport and free movement, and adds crucial pacts on health, food security and Swiss participation in the European space agency and the Horizon Europe and Erasmus+ programmes. In addition, it will allow it to fully enter the internal electricity market in the EU. The objective of the Federal Council is “stabilize and future-proof the proven bilateral track“. The Federal Council approved the sending of this package to the Parliamentor, proposing to subject it to an optional referendum to guarantee its democratic legitimacy on sensitive issues such as salary protection. Switzerland’s weight is undeniable: in 2023, bilateral trade in services reached €245 billion, representing almost 9% of the EU’s total services trade. Forecasts in sight? The geopolitical board will continue to move. If Iceland eventually joins the EU, the pressure on Norway will be immense. As conservative leader Søreide arguesNorway would be in a “completely different situation” if its EFTA partner makes the leap. For its part, Switzerland … Read more

The metro has been splitting Rivas in two for decades. The city council has a plan to cover it up and has already presented it to Madrid

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The Rivas Vaciamadrid City Council has registered before the General Directorate of Infrastructure of the Community of Madrid its project to cover 2.5 kilometers of Metro Line 9B. This is a project that aims to transform part of the town’s urban layout, and the deadline for issuing its technical report has already opened. We tell you all the details. What exactly is this about? Just like they count From the town hall itself, the project consists of burying or covering the section of road that runs above ground through Rivas Vaciamadrid between the Cerro del Telégrafo Sports Center and the Rivas Futura station. They are 2.5 kilometers long and 30 meters wide which, if covered, would stop acting as a physical barrier that divides the municipality in two. On the surface, it is planned to extend the Linear Park, creating a corridor with green spaces for public use. The project also includes the construction of a fourth Metro station in Rivas, located on José Saramago street. Deadlines. The City Council had a technical meeting on February 27 with the General Directorate of Infrastructure, where it presented the solution. A week later, on March 4, it was officially registered, and now the Community of Madrid has three months to decide whether to move forward at a technical level. According to collect El Diario, the council has expressly requested “agility” from the regional administration. Tpolitical background. The fourth season brings them. And it is that according to Diario de Rivas, the Community of Madrid has already pointed out on more than one occasion that this infrastructure “is not justified on a technical level.” The City Council, for its part, insists that the project “is the result of months of rigorous and reliable technical work and that it meets the necessary requirements to move forward towards its execution.” The General Directorate of Infrastructure, for now, has limited itself to confirming that there was a meeting. What the data say. The City Council supports its position to move forward with the project through a survey in which they say that 78% of Rivas residents recognize the importance of this project. The organization frames it within its Rivas 2030 Urban Agenda, where it appears as one of its most notable projects to reconfigure its urban model. What happens now? The ball is in the court of the Community of Madrid. Before the end of June, the technical response from the General Directorate of Infrastructure should arrive. This report will determine if the project can move forward as planned, if it needs modifications or if the proposal (especially the new station) encounters obstacles from the regional administration. The Town Hall has expressed his confidence that the Community “facilitates the progress of an action long awaited by the citizens of Rivas”, but it seems that we will have to wait to find out if it finally materializes as the city council wants. Cover image | Google Maps In Xataka | BYD is already studying entering Formula 1, according to Bloomberg. And it is not a whim, it is a necessary step

We have not understood for decades why chronic pain punishes women more. Finally we have the answer

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Historically, medicine has grappled with an undeniable gender gap in which women Women suffer chronic pain more frequently than men, and on top of that their pain flares for much longer. This is something that many doctors have considered ‘normal’ and has been dismissed with psychological biases. But now science has seen that an explanation should not be sought in the mind, but in the immune system. Against pain. This is the objective that medicine has right now, since it is undoubtedly a situation that for many people can be unbearable. That is why the magazine Science Immunology publish now a new study that offers a paradigm shift in our understanding of the biology of pain. The result of this is that he has managed to find the key to some types of white blood cells called monocytes and in its direct relationship with testosterone. What’s happening? When an injury is suffered, such as a blow, the body tries to defend itself with an inflammatory response. One of its components is pain, which is a necessary alarm signal to warn that something is wrong, but once the tissue begins to heal, it is logical that this alarm goes off. But this is where the body’s defense cells come in, monocytes, which act as ‘firefighters’ by releasing proteins called interleukin-10. Here the research team has been able to see that this interleukin-10, abbreviated as IL-10, acts directly on sensory neurons to “turn off” hypersensitivity and therefore pain. The problem, and here lies the importance between sexes, is that men resolve this inflammatory pain much faster because they produce a greater amount of this protein. The reason. Testosterone. This male sex hormone stimulates monocytes to produce higher levels of IL-10 after injury, and therefore pain can be better reduced. But in women this level of testosterone is much lower, and therefore the production of this natural ‘painkiller’ is lower, which causes the sensory neurons to take much longer to stop giving the signal that generates pain. Your demonstration. Beyond doing so in animal models, the research team has been able to validate the experiments with human data from the AURORA studiowhich is a project that evaluates patients who have suffered traffic accidents and severe trauma. Here the clinical data confirmed the laboratory’s suspicions, since they saw that the elimination or reduction of IL-10 activity in monocytes significantly delays the resolution of pain in both sexes, validating that this hormone-mediated immunological difference is exactly the same in humans. In the future. This discovery is not just another biological curiosity to close a historical debate, but it has important therapeutic implications. And right now the severe pain crisis has to be treated with opiates on many occasions, which have a long list of side effects. But upon discovering this cellular mechanism, the researchers tried administering Resolvin D1a compound that promotes the resolution of inflammation. Here it was clearly seen how pain was reduced equally in both sexes. This is why we are at the gateway to a new generation of non-opioid therapies that specifically modulate the immune system. But what is most important about this study is that it highlights the need to leave behind the “one size fits all” model in medicine to move towards more personalized medicine. Images | Redd Francisco In Xataka | Medicine has been using opioids to relieve pain for centuries. Science finally has an alternative

Iran has spent decades excavating its “missile cities.” Satellite images have just revealed that they are a death trap

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For years, Iran has shown the world tunnel videos endless tunnels dug under mountains, with military trucks circulating between missiles lined up as if they were cars in an underground subway. It was understood that many of these facilities extend kilometers underground and are part of one of the military fortification programs. most ambitious in the Middle East. What almost no one knew until now is to what extent this gigantic hidden labyrinth could become a key piece of the current conflict. The cities, but with missiles. Yes, for decades, Iran has excavated an extensive underground base network known as “missile cities”, complexes hidden under mountains and hills intended to protect its enormous ballistic arsenal against air attacks and guarantee the regime’s retaliation capacity even in the event of open war. There are numerous videos Officials released in recent years where we could see long tunnels illuminated by artificial lights, windowless corridors and convoys of trucks loaded with missiles ready to move to the surface, an entire military architecture designed to hide thousands of short and medium range projectiles away from spy satellites and enemy bombers. Some installations even incorporate silos dug into the rock or mechanical systems on rails to move missiles within underground galleries, a perfectly assembled choreography reflecting a strategic project conceived to ensure arsenal survival Iranian in a protracted conflict. The images that reveal the paradox. However, the war has begun to show the unexpected reverse of that strategy. Recent images from space have revealed Smoldering remains of destroyed launchers and missiles near the entrances to several underground complexes, a sign that systems hidden underground are becoming extremely vulnerable at the moment when they must go outside to shoot. It makes sense. American and Israeli surveillance planes, armed drones and fighters They patrol constantly over the areas where these facilities are located, observing the entrances to the tunnels and attacking the launchers as soon as they appear on nearby roads or canyons. In other words, what for years was a system designed to hide mobile weapons It thus becomes a relatively predictable pattern: tunnel entrances, exit roads and deployment areas that can be monitored from the air and destroyed as soon as activity is detected. From strategic refuge to death trap. They remembered in the wall street journal A few hours ago this change has revealed a structural problem in the very concept of missile cities. Underground complexes are very difficult to destroy from the air, but they are also fixed installations whose location is known by Western intelligence services. In practice, this means that much of the arsenal remains stored in specific places while enemy planes continually fly over the airspace, waiting for the moment when the launchers come out to act. Many military analysts summarize the dilemma in a simple way: What was previously a mobile and difficult to locate system is now concentrated in fixed points, which facilitates its surveillance and reduces its capacity for surprise. Commercial satellite images themselves show destroyed launchers As soon as they left the mouths of the tunnels, fires were caused by leaked fuel and access to facilities bombed with heavy ammunition. Missile base north of Tabriz in Iran. The image on the left belongs to February 23, the one on the right from March 1 after the first attacks The air offensive against underground infrastructure. As the first week of war approaches, the military campaign has begun to focus increasingly on these infrastructures. They told Reuters that the first phase of the attacks focused on destroying visible launchers and surface systems capable of firing at Israel or US bases in the region, while the second stage aims straight to the bunkers and buried warehouses where missiles and equipment are stored. Israeli aviation, with American support, has attacked hundreds of positions and has managed to drastically reduce the number of launches, while an almost constant air offensive that hits targets continues. both in Iran and Lebanon during the same missions. The stated objective is to progressively degrade Iran’s ability to launch ballistic missiles and drones until it is completely neutralized. Missile base north of Kermanshah in Iran. The image on the left belongs to February 28, on the right it belongs to March 3 A gigantic arsenal underground. The actual scope of these facilities remains difficult to determine. There are military estimates that place the Iranian arsenal before the war between about 2,500 and up to 6,000 missilesstored in different facilities throughout the country, many of them excavated under mountains or in remote areas of the territory. Despite the attacks, Iran has managed to launch more than 500 missiles against Israel, US bases and targets in the Gulf since the start of the conflict, although many have been intercepted and the pace of salvos has decreased rapidly. That drop suggests that attacks on launchers and storage centers are beginning to erode the country’s ability to respond. The strategic dilemma. The result is a strategic paradox that is just beginning to become visible. Missile cities were designed to protect the core of Iranian military power and ensure its ability to retaliate, but in a scenario where the enemy dominate the air and watch constantly the entrances to these complexes can become choke points for the arsenal itself. Iran has spent decades excavating these underground bases with the intention of making its missiles invisible. But satellite images of the war are showing something very different: that this labyrinth of tunnels, designed as a shelter, can become one of its greatest vulnerabilities when the launchers are forced to surface under the look constant flow of planes, drones and satellites. Image | X, Planet Labs In Xataka | We had seen everything in Ukraine, but this is new: neither drones nor missiles, bulldozers have reached the front In Xataka | You’ve probably never heard of urea. The missiles in Iran are destroying their production, and that will affect your food

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