The buzzword in the world of sports and weight loss is “autophagy.” Sounds good, the only problem is that it’s bullshit
On December 7, 2016, Yoshinori Ohsumi He stood on the stage of the Medical Classroom of the Karolinska Institute in Stockholm and began to explainin detail, “the discoveries of the mechanisms of autophagy.” Three days later, in front of a completely packed auditorium, won the Nobel Prize in Medicine and Physiology. Now, dozens of people are dedicated to using these mechanisms to lose weight. Isn’t it a beautiful example of the value of basic science? It would be, in fact, if it weren’t for the fact that it’s all a hoax. Autophagy exists. Of course yes: as I say, the 2016 Nobel Prize went to its discoverer. It is a cellular mechanism that recycles damaged components. We know that when nutrients are lacking or there is stress, the cell wraps parts of itself (damaged proteins, old organelles like mitochondria) in double-membrane vesicles called autophagosomes, which fuse with lysosomes to degrade and reuse those components. It is something essential in cellular life. Basic, essential: essential to preserve the functionality of tissues throughout life. This maintains internal well-being, obtains extra energy or materials and contributes to cellular defense. It reaches such a point that a few days ago, the journal Nature Immunology explained in detail how all this is a fundamental piece in longevity. What’s the problem then? Measuring its effect on humans is complex. After all, direct markers They are difficult to grasp outside of biopsies or highly controlled laboratory conditions. Indirect markers abound, yes; but they are not very specific. This makes us know that prolonged fasting activates the mechanisms of autophagy, yes; but we don’t know anything about anything like intermittent fasting or any type of diet doing that. In fact, even when we can see increases in autophagy gene expression, we cannot make the leap to clinical benefits. So… Can it be used, then, to lose weight? Well no. The truth is that selling it as a “trick” to lose weight is going too far: weight is lost due to a caloric deficit, not by “eating yourself.” Ultimately, all the examples given are nothing more than the extrapolation of isolated cellular models. There is no no kind of scientific evidence that endorses any of that. The only thing we know about autophagy at a clinical level is that, well, it sounds good: it sells. And, really, that’s enough. Saving the distance, ‘autophagy’ is the new ‘quantum diet’: something that sounds scientific, that has the endorsement of the community of experts and that means absolutely nothing. A perfect breeding ground for charlatans. Is it a scam then? I wouldn’t say that much. What’s more, we may find out in the next few years that autophagy mechanisms do indeed do things in normal diets. The important thing is that, along the way, all those who want to take advantage do not destroy the credit that Oshumi achieved with his revolutionary work. Image | Marco Vitiello In Xataka | The lies of the nutritional pyramid: from pedagogical tool to corporate battleground
