It is to “eat” your bacteria

Every time you go to the beach or walk under an intense sun, the skin starts a complex chain of reactions on its surface. You can think automatically In vitamin D and in the burnsbut at the microscopic level a fascinating ‘battle’ is fought where bacteria that cover the skin have a leading role. And what they do is surprising: literally, they “eat” one of the most negative effects of the sun, altering the way our body responds to it.

The sun is a threat to the immune system. To understand this story, you must first know that the sun does not only bronze. Ultraviolet radiation (UV) acts as a powerful ‘switch’ for the immune system. When UV rays affect the skin, it converts a very abundant molecule called urocanic acid In its ‘twin’, cis-urocanic acid.

This new molecule, the CIS-UA, has a very clear mission: to be a powerful Immunosuppressive. It is as if it disarms the ‘defenses’ in the skin so that they do not react to the presence of the sun. As a positive point, it allows us to use the UV light phototherapy to calm inflammatory diseases such as dermatitis. But it also has a negative point, since not having the defenses ‘on alert’ can hinder the elimination of sun damaged cells that in the long term they can in the long term evolve to skin cancer.

Bacteria again demonstrate their importance. A published study by the magazine Journal of Investigative Dermatology It has given light to why the immunosuppressive effect of CIS-UA in a real environment was not always as powerful as expected in the laboratory. The answer to this dilemma was in the billions of microorganisms that inhabit the skin: the Microbioma.

In a series of animal experiments, the researchers saw that when exposing the skin to UC radiation, the population of certain bacteria (especially the Staphylococcus epidermidis) He shot. And it wasn’t a coincidence. This bacterium It has an enzyme of the catalase type that functions as a perfect ‘crusher’ to eliminate the CIS-UA.

In essence, while the sun produces this immunosuppressive molecule, the bacteria of our skin use it as a source of food, limiting its amount and, therefore, its effect on our defenses.

They demonstrated it by eliminating bacteria. To give more validity to the theory presented, the researchers disinfected the skin of the mice to eliminate their microbiome. When exposing them to UV light, the immunosuppressive effect shot. Without bacteria that end the CIS-UA, the molecule could continue ‘silence’ to the skin defenses and give rise to having a greater probability of cancer.

But when they only left the bacteria on the skin Staphylococcus epidermidis The defenses were not depressed. This was a great proof that the bacteria and its enzyme were responsible for regulating the effect of the sun on the skin.

A door to sun’s sun’s sun. These discoveries are not only to satisfy scientific curiosity, but opens the door to new medical and cosmetic applications. For patients with psoriasis or atopic dermatitis, a simple step such as disinfecting the skin before applying UV light therapy can greatly enhance its effectiveness by suppressing skin defenses.

For the day to day, we are interested in otherwise: limit immunosuppression to maintain active defenses in the skin against the damage that prolonged exposure to the sun can do. The creams of the future could not only block UV rays, but also include ‘probiotics’ or ingredients that feed these beneficial bacteria. We would be in this way by promoting our natural defenses instead of depending solely chemicals. Although for now the sun cream is still essential.

Bacteria are one of us. Although bacteria are almost always related to a pathology, the reality is that There are about 100 billion microorganisms in the body (ten times more than cells). And the reality is that they do important functions such as in the human microbiota, whose alteration has been related With serious diseases such as Alzheimer’s wave depression. Now we see a new beneficial function of the bacteria that live with us, and that are more allied than enemies.

That is why the investigation is pointing out that A healthier chocolate must focus on probiotics or that one of the most famous diets such as intermittent fasting It has positive effects In our health, But also negative. This makes your research right now in the priority of numerous groups and very diverse disciplines.

Images | CDC Morgan Alley

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