After the mosquitoes and the man himself, snakes usually take third place in The list of more deadly animals for the human being. According to estimates of the World Health Organization (WHO), between 81,410 and 137,880 people die every year as a result of the bite of these reptiles. AI can help change this.
AI to the rescue. A group of researchers has demonstrated the utility of deep learning tools (Deep Learning) In the design of proteins capable of neutralizing, at least partially, the effect of the venom of some the steps (Elapidae), The snake family that includes the cobras, coral snakes and mambas.
Three fingers. The study focuses on the calls “Toxins of the three fingers”(3FTX), called by the form of tridents that have the proteins that make up this family. These compounds are potentially lethal neurotoxins, that is to say they have the ability to attack our nervous tissue and involve a risk to the lives of people who are poisoned.
As the team explains, these toxins are responsible for the anti -speakers, the antidotes used to counteract the venom of snakes, are not effective. The reason is that these toxins are capable of “evading” To our immune system, reducing the effectiveness of some treatments.
For now, in mice. The team responsible for the development of the new antitoxins put them to the test in mice. The team experienced with different types and doses of poison and different antitoxins, achieving survival rates of between 80% and 100%.
The details of the study have been published In an article In the magazine Nature.
Lowering costs. The new technique opens a new way to the creation of molecules aimed at counteracting the different toxins that affect people who receive the bite of a poisonous snake, offering new advantages. First, to reduce the time dedicated to the process of searching for new useful compounds in this field.
Less time dedicated to research implies a lower cost, but it is not the only factor that would help reduce the “invoice” of antidotes. According to the equipment, the new compounds can be synthesized using microbes, which would avoid traditional production methods.
“The antitoxins we have created are easy to discover using only computational methods. They are also cheap to produce and robust in laboratory tests,” stood out in a press release David Baker, study co -author.
Better access.Under costs and higher production facilities imply better access to these antidotes, something key if we take into account that it is in developing countries where snake bites more problems cause. “I trust that protein design make treatments against snake bites more accessible to people in developing countries,” Susana Vazquez Torres addswho led the new job.
The inheritance of a Nobel. David Baker’s name can be familiar: in 2024 He received the Nobel Prize in Chemistry “For the computational protein design”, a prize he shared with Demis Hassabis and John M. Jumper. Baker’s prize recognized his work in the construction of proteins never observed in nature, all through the combination of amino acid sequences.
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Image | Anil Sharma
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