Sometimes extreme situations require extreme measures, at least in the field of medicine and health. Perhaps to many, the idea of microbiota transplants It seems to them that it belongs to this range of extreme measures. Perhaps more so if we refer to this therapy by its first and last name, because we are talking about fecal microbiota transplants.
Let’s start at the beginning, explaining what exactly these transplants are. Although its name is quite descriptive.
The central idea of this treatment is to take a sample of intestinal microbiota from a healthy person and transfer it to the patient’s intestine. For this, samples of fecal matter are used, feces from the donor that are treated for introduction into the recipient’s gastrointestinal system.
The process begins, therefore, by taking a sample (or several) of the donor feces. First of all, it must be verified that these feces do not contain pathogens but that the “good bacteria” of our digestive system predominate in the sample.
Once this filter has been passed, the sample is prepared in different ways depending on how it will be administered. One possibility is to dry, freeze and encapsulate part of these samples to administer them. through a pill.
However, the most conventional options involve diluting the sample in saline water and then filter it and enter it into our system gastrointestinal, either through a tube introduced through the mouth or nose and that would reach our stomach; either through a colonoscopy, an endoscopy through the colon.
Fixing the imbalance
And all this, for what? Interestingly, if we are transplanting microbes from one person to another, the reason is to fight against a pathogenic bacteria, called Clostridioides difficile (C. diff). This is a bacteria that normally inhabits our system gastrointestinal without causing major discomfort. But not always.
In these cases, C. diff It can take over the inside of our intestine, wreaking havoc on it. C. diff They feed on toxic compounds that they metabolize from some foods we consume and that can end up causing even more damage to our microbiota.
This infection It is considered the main cause of diarrhea associated with medical treatments, but this It’s not your only symptom.These include fever, pain or tenderness in the stomach, loss of appetite and nausea, symptoms of gastroenteritis. Some more serious cases They can lead to dehydration, blood or pus in the stool, and kidney failure.
One of the problems associated with this bacteria is the appearance of recurrent infections: many patients become ill again between two and eight weeks after the original infection.
The potential of this tool is yet to be explored. A recent study, for example, explored the possibility of using this type of intervention to improve sports performance. A luck of “fecal doping” similar in some ways to existing techniques. Sport, and especially elite sport, can affect our microbiome, which in turn can be exploited in favor of the athletes themselves.
These transplants have even been proposed in veterinary. Specifically, to help preserve koalas, as we saw in a studio also presented in 2019 in the magazine Animal Microbiome.
Over the last few years we have been discovering new links between our gut microbiome and seemingly very distant aspects of our health. Now we even know that there is a connection between our brain and this one. Unfortunately, we still do not understand the causal relationships operating in this connection.
In this sense, recently we came across a link between these transplants and autism. a study published in 2019 in the magazine Scientific Reports observed that symptoms linked to autism were reduced among those who had received this type of transplants.
Image | shameersrk / chriskeller
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