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The peptide similar to type 1 glucagon (or LPG-1) is a key hormone in the regulation of appetite and the feeling of satiety. His name may not be immediately familiar to us but we have heard long and taught about compounds that act as their analogues. Compounds such as Semaglutida, which if it still doesn’t sound to us probably does one of the names with which it is marketed: Ozempic.
New hormone. Now a study announces a New mechanism which could lead to similar results. The difference is in the hormone in question. And it is that the new work has found a hormone also linked to our appetite, which they have baptized as Raptina. It is a hormone also linked to our sleep cycles.
Sleep and obesity. Exists A relationship quite Documented between sleep and overweight quality (and also with certain metabolic diseases). We can intuit that people who sleep worse rest less and therefore are less likely to burn the calories they consume, but some previous studies seem to have observed that this is not the case.
Rather opposite: When we sleep more this does not seem to affect the energy we spend so much but We tend to consume it more. In other words, when we rest more we eat more calories, but without substantial changes in our physical activity.
The hormones of appetite. To explain this phenomenon, the team was searching for compounds that could be behind this increase in our appetite. They found a hypochipothalamic hormone derived from the RCN2 protein (Reticulocalbin-2) to which they called Raptina (Raptin). This hormone is present in both mice and humans.
The team observed that the presence of this hormone reached its peaks while we slept, and that the lack of sleep was linked to a lower presence of the compound in our body. They also observed that this hormone adhered to metabrotropic receptors 3 (GRM3) in the Hypothalamus neurons inhibiting appetite, and in the stomach also inhibiting gastric emptying.
Finding the finding. The team contrasted its observations, first analyzing how sleep problems affected the secretion of this hormone in patients with obesity. Secondly, they found through a genetic analysis that people with variants in the RCN2 gene that reduced the ability to segregate this hormone were linked to obesity and the so -called “night feeding syndrome”.
The details of the study were published In an article In the magazine Cell Research.
A race at multiple speeds. The success of Ozempic, the drug against diabetes converted into treatment to lose weight, has led numerous laboratories to redouble their efforts in the search for a compound capable of emulating its fame.
The advantage in this “career” has been obtained with the same effects.
Until one of those treatments arrives, what we can detach from this study is that, if our goal is to lose weight, an indispensable step is to try to sleep more and sleep better.
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