We still don’t know how to cure blindness. So we’re going into space to try to solve it once and for all.

We often wonder what space research is for. Is it worth investing huge amounts of money in exploring beyond our planet? Depending on who we talk to, they may give us a different answer, but if there is one thing that is clear, it is that part of the research that is done in space generates a return on Earth. For example, certain research conducted on the International Space Station (ISS) may help treat certain types of blindness on our planet.

This research has been carried out over the last 10 years by the company LambdaVisionin collaboration with the commercial service provider of the ISS National Laboratory Tango Space. Basically, this company is dedicated to manufacturing artificial retinas to help restore vision to people with age-related macular degeneration or retinitis pigmentosa. The manufacture of artificial retinas is not new. It is something that has been investigated on Earth for some time, but there are some handicaps in the process that are resolved quite well in space.

All advantages. In the last 9 years have been carried out 10 research missions to the ISS aimed at perfecting the development of artificial retinas in microgravity. In this time, they have managed to improve uniformity, optical performance and reproducibility. In addition, less material is needed, which is not only advantageous in economic terms. It also improves the biocompatibility of the final product.

A microbial solution. Both age-related macular degeneration and retinitis pigmentosa cause vision problems due to loss of photoreceptor cells in the retina. Under normal conditions, these cells are responsible for capturing the light that reaches the eye and converting it into electrical signals that are sent through the optic nerve to the brain, where they are interpreted and transformed into what we see. If they are damaged, signals are not sent correctly and vision is obscured or impeded.

For this reason, research has been carried out for some time with bacteriorhodopsin, a protein used by some extremist bacteria to obtain energy from light. In a way, it is similar to what happens in the retina. Light is transformed into energy, which can be used to send signals to the brain. Therefore, artificial retinas can be made using this protein.

Layers and more layers. Briefly, artificial retinas are made up of hundreds of layers of bacteriorhodopsin, arranged on top of each other. Although in reality the process is somewhat more complex. Typically, a substrate is used that is placed in a beaker in which bacteriorhodopsin, a polycationic polymer that helps assemble the layers on the substrate, and a washing solution are deposited. Thus, the layers that give rise to the definitive retina are arranged.

The problem of gravity. Just as when you put sugar in coffee it goes to the bottom of the cup if we don’t stir it constantly, the same thing happens in the beaker. The denser molecules sink to the bottom. On the other hand, precisely because of this difference in densities, convection currents are created that cause an uneven coating.

In short, the layers do not remain the same. This could affect vision, as the light is not distributed equally and the resulting signals are not uniform. Images would be generated, but they would be distorted. To prevent this from happening, the area in which the layers are most homogeneous is cut and the rest is discarded. This represents a huge waste of material and, at the same time, great difficulty in scaling the process so that it is profitable to carry it out in large quantities.

CubeLab Content

The solution is in space. All problems that lead to heterogeneous layer distribution are due to gravity. If we do not have that downward attraction, the sugar would not settle to the bottom of the cup. For this reason, LambdaVision partnered 4 years ago with Space Tango to use its CubeLab, a compact experimental module in which experiments can be carried out in an automated manner.

To manufacture artificial retinas, instead of doing the substrate and beaker procedure, a bag with liquid and a chamber with the substrate are used, so that the solution is pumped into the chamber alternately.

All advantages. In addition to the advantages that we have already seenranging from reproducibility to increased optical performance, this process has more benefits. To begin with, it is carried out automatically. Once it is launched, it does not require the intervention of any astronaut. In fact, if there is a problem, the process stops and a notice is sent to Earth, from where solutions can be searched and executed remotely.

On the other hand, all the material and machinery are very compacted. The payload involved within the ISS is minimal, so many retinas can be obtained with a minimal footprint.

And now what? By the end of this year, LambdaVision wants to launch a new mission, in which it is expected to look for ways to increase production volume and optimize processes. Thus, if all goes well, they will be able to begin preclinical trials by the end of 2027 or beginning of 2028. There is still a long way to go before these artificial retinas can be used to treat blindnessbut the investigation is going from strength to strength. Of course, there is research in space that is most useful here on Earth.

Image |Magnific | Tango Space

In Xataka | Hundreds of blind people received bionic implants to restore their sight. Now they are out of support