The Nobel Committee at the Karolinska Institute of Stockholm has done it again. He has rewarded one of those investigations that, for years, seemed like a page note in textbooks, but today are the basis of revolutionary treatments. He Nobel Prize for Physiology and Medicine of 2025 He has been granted jointly to Japanese Shimon Sakaguchi and Americans Mary E. Brunkow and Fred Ramsdell for “their discoveries about Regulatory T cells And the role of Foxp3 gene In the immune function “
The beginning. Already in the previous decade, Sakaguchi had identified a subset of T lymphocytes that did not attack, but did the opposite: they suppressed the activity of other T lymphocytes. They were pacifying cells, a kind of riot police of the immune system. In 1995, He published a job Key that characterized these cells, today known as regulatory T cells (TREGS).
The finding was transcendental. Sakaguchi showed that without these tregs, The immune system went crazy and began to attack the tissues of the body itself, causing devastating autoimmune diseases. He had discovered the natural mechanism of the body to maintain tolerance and avoid self -destruction. But the key piece of the puzzle was missing: what made a T cell become a peacemaker and not a soldier?
Brunkow and Ramsdell. Although this discovery was transcendental, the reality is that there was a lot of skeptic that he did not believe in his theory. But the answer to the big question that stayed in the air came in 2001 (still far from the year 2025 and the delivery of this award). Here, on the one hand, Mary E. Brunkow’s team investigated a rare and deadly disease Autoimmune in children called IPEX syndrome. The investigation pointed to a gene as a cause of this disease: Foxp3.
On the other hand, Fred Ramsdell’s team was studying a mouse model with very similar symptoms and reached the same conclusion: The defective gene was Foxp3.
The connection. The connection was immediate and explosive: Foxp3 was the “master switch”. It is the gene that, when activated in a T lymphocyte, gives you the instructions to become a TREG. Without functional FOXP3, there are no regulatory T cells, and the immune system is uncontrolled. Sakaguchi’s discovery finally found his genetic explanation and already gave him enough weight so that the scientific community saw that he had sat a great precedent.
A revolution. This double discovery, Sakaguchi’s cell phone and Brunkow and Ramsdell’s genetic, has completely changed the immunology paradigm and has opened two great therapeutic pathways with immense potential.
On the one hand, the door opens up to the fight against autoimmune diseases since with the lack of tregs the body attacks itself. The solution in this case is to increase this type of cells, and there are already different clinical trials to extract patient T cells, “convert” them into the laboratory and re -inject them to the patient. Something we now know as ‘immunotherapy’.
But it also serves for the fight against cancer. In these cases it has been seen how tumors are ‘intelligent’ and surround themselves with tregs to protect themselves to the immune system that tries to end these cells. These pacifying cells prevent “soldier” T lymphocytes from attacking cancer. The new immunotherapies seek precisely to temporarily deactivate these tregs or block the action of Foxp3 in the tumor environment, eliminating the protective coat of cancer so that the immune system can destroy it. This has been especially promising in tumors such as lymphoma.
Time has passed. The most surprising of all this is the large amount of time between the initial discovery and recognition with a Nobel. If it is true that it has been expected to have a crucial relevance within the clinical aspect, with trials that give very good results for diseases that are really serious.
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