What makes us fat? The question is simple, but the answer is not. We could simply say that it is a mathematical issue, calories that enter through calories that burn, but it would be to simplify the matter too much, forgetting that each body metabolizes food differently and that different foods and combinations of food can lead to slightly different results.
A simple protein. The deficiency of a simple protein, CD44, Avoid in an experiment that a group of mice will gain weight even being subjected to a high diet in fat. The team responsible for the experiment tried to inquire into the role that this protein plays in metabolic health and obesity, a role, according to the results, of great importance.
“We had previously pointed out that the deficiency of CD44 suppressed neuroinflamation. Give Metabolic, ”he explained In a press release Cheng Sun, co -author of the study.
CD44. But what exactly is this protein and what do we know about its function in the body? CD44 is one Transmembrane proteina protein located in the cell membrane that crosses this layer that covers the cell. As explained by the team itself, this protein “plays an essential role in transcending extracellular stimuli within intracellular signal waterfalls”, thus contributes to metabolic regulation. This protein is also of special importance for cancer cells.
Closing the step. The team genetically modified a group of mice to force the lack of this protein. In doing so, they observed that, even when they were provided with a high fat diet, the modified mice did not fat while the control population (not modified mice) did gain weight until developing obesity.
The team responsible for the study He also points out The possible mechanism behind this relationship between lack of protein and thinness. They explain that this relationship can be attributed to the suppression of the so -called adipogenesis in the white adipose tissue. That is, the creation of the cells responsible for storing precisely where we accumulate more is avoided.
The details of the study were published In an article In the magazine The American Journal of Pathology.
A new route. The team compares this path for weight loss with the one used by drugs such as Ozempicthe so-called LPG-1 (since its competence active emulates the effects of the peptide similar to type-1 glucagon). Very different routes in each case.
As detailed by the team itself, the agonists of the GLP-1 receptors regulate the appetite and the metabolism of the glucose; Inhibition of the CD44 protein, meanwhile, acts preventing the formation of fat cells. This difference, they emphasize, implies that protein inhibitors could be used as accessories to treatments such as Ozempic when weight loss is sought.
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